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Title: 2D Kinetics and Forced Dissociation of Selectin-ligand Bindings
Author: Long M(龙勉)
Issued Date: 2005-12-19
Conference Name: US-China NSF Workshop of Young Investigator Awardees in Bio and nano Mechanics and Materials
Abstract: Cell adhesion is crucial to many pathophysiological processes, such as inflammatory reaction and tumor metastasis. It is mediated by specific interactions between receptors and ligands, and provides the physical linkages among cells. For example, interactions between selectins and glycoconjugate ligands mediate leukocyte initially tethering to and subsequently rolling on vascular surfaces in sites of inflammation or injury, which is determined by their fast kinetic rates. To mediate cell adhesion, the interacting receptors and ligands must anchor to apposing surfaces of two cells or a cell and the substratum, i.e. , the so-called two-dimensional (2D) binding, which differs from interactions in the fluid phase, i.e. , the three-dimensional (3D) binding. How structural variations and surface environments of interacting molecules affect their 2D kinetics, and how external forces manipulate their dissociation has little been known quantitatively, and nowadays attracts more and more attentions.
Subject: 生物力学
Corresponding Author: 龙勉
Source: 生物医学工程学杂志,2004,21(增):3
Content Type: 会议论文
URI: http://dspace.imech.ac.cn/handle/311007/13887
Appears in Collections:力学所知识产出(1956-2008)_会议论文

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