2D Kinetics and Forced Dissociation of Selectin-ligand Bindings

IMECH-IR > 力学所知识产出(1956-2008)

	2D Kinetics and Forced Dissociation of Selectin-ligand Bindings
	Long M(龙勉)
会议录名称	生物医学工程学杂志,2004,21(增):3
	2005-12-19
会议名称	US-China NSF Workshop of Young Investigator Awardees in Bio and nano Mechanics and Materials
摘要	Cell adhesion is crucial to many pathophysiological processes, such as inflammatory reaction and tumor metastasis. It is mediated by specific interactions between receptors and ligands, and provides the physical linkages among cells. For example, interactions between selectins and glycoconjugate ligands mediate leukocyte initially tethering to and subsequently rolling on vascular surfaces in sites of inflammation or injury, which is determined by their fast kinetic rates. To mediate cell adhesion, the interacting receptors and ligands must anchor to apposing surfaces of two cells or a cell and the substratum, i.e. , the so-called two-dimensional (2D) binding, which differs from interactions in the fluid phase, i.e. , the three-dimensional (3D) binding. How structural variations and surface environments of interacting molecules affect their 2D kinetics, and how external forces manipulate their dissociation has little been known quantitatively, and nowadays attracts more and more attentions.
文献类型	会议论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/13887
专题	力学所知识产出(1956-2008)
通讯作者	Long M(龙勉)
推荐引用方式 GB/T 7714	Long M. 2D Kinetics and Forced Dissociation of Selectin-ligand Bindings[C]生物医学工程学杂志,2004,21(增):3,2005.

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