The Mitogenic and Anti-Apoptotic Activity of Tumor Conditioned Medium on Endothelium

IMECH-IR > 力学所知识产出(1956-2008)

	The Mitogenic and Anti-Apoptotic Activity of Tumor Conditioned Medium on Endothelium
	Li AL; Li HW; Jin G(靳刚); Xiu RJ
会议录名称	CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2003,29(3-4):375-382
	2003-02-20
会议名称	5th Asian Congress for Microcirculation, FEB 20-22, 2003 MANILA, PHILIPPINES
摘要	This study was designed to observe the effect of tumor conditioned medium (TCM) on the proliferation and apoptosis of human umbilical vein endothelial cells (HUVECs). HUVECs were exposed to TCM from breast carcinoma cell line MDA-MB-231, then we measured their proliferation, apoptosis and cell cycle distribution by MTT and flow cytometery (FCM). Following the stimulation of TCM, HUVECs showed higher pro-mitogenic and anti-apoptotic ability than did the negative control group (ECGF-free medium with 20% FBS), but a similar ability to the positive control group (medium with ECGF and 20% FBS). From these results, we can conclude that breast carcinoma cell line MDA-MB-231 could secret soluble pro-angiogenic factors that induce HUVEC angiogenic switching, including cell cycle progression, proliferation and growth. The role and character of these factors remain to be further studied.
WOS记录号	WOS:000188240800031
收录类别	CPCI-S
语种	英语
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	会议论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/13896
专题	力学所知识产出(1956-2008)
通讯作者	Jin G(靳刚)
推荐引用方式 GB/T 7714	Li AL,Li HW,Jin G,et al. The Mitogenic and Anti-Apoptotic Activity of Tumor Conditioned Medium on Endothelium[C]CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2003,29(3-4):375-382,2003.

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