IMECH-IR  > 非线性力学国家重点实验室
Generating artificial homologous proteins according to the representative family character in molecular mechanics properties - an attempt in validating an underlying rule of protein evolution
Liu X(刘鑫); Zhao YP(赵亚溥); Zhao YP(赵亚溥)
Source PublicationFEBS Letters
2010
Volume584Issue:5Pages:1059-1065
ISSN0014-5793
AbstractThe molecular mechanics property is the foundation of many characters of proteins. Based on intramolecular hydrophobic force network, the representative family character underlying a protein’s mechanics property is described by a simple two-letter scheme. The tendency of a sequence to become a member of a protein family is scored according to this mathematical representation. Remote homologs of the WW-domain family could be easily designed using such a mechanistic signature of protein homology. Experimental validation showed that nearly all artificial homologs have the representative folding and bioactivity of their assigned family. Since the molecular mechanics property is the only consideration in this study, the results indicate its possible role in the generation of new members of a protein family during evolution.
Subject Area交叉与边缘领域的力学
DOI10.1016/j.febslet.2010.02.010
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Indexed BySCI
Language英语
WOS IDWOS:000274862900037
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/33082
Collection非线性力学国家重点实验室
Corresponding AuthorZhao YP(赵亚溥)
Recommended Citation
GB/T 7714
Liu X,Zhao YP,Zhao YP. Generating artificial homologous proteins according to the representative family character in molecular mechanics properties - an attempt in validating an underlying rule of protein evolution[J]. FEBS Letters,2010,584,5,:1059-1065.
APA Liu X,Zhao YP,&赵亚溥.(2010).Generating artificial homologous proteins according to the representative family character in molecular mechanics properties - an attempt in validating an underlying rule of protein evolution.FEBS Letters,584(5),1059-1065.
MLA Liu X,et al."Generating artificial homologous proteins according to the representative family character in molecular mechanics properties - an attempt in validating an underlying rule of protein evolution".FEBS Letters 584.5(2010):1059-1065.
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