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Stabilizing to disruptive transition of focal adhesion response to mechanical forces
Kong D(孔冬); Ji BH(季葆华); Dai LH(戴兰宏)
Source PublicationJournal of Biomechanics
2010-08-18
Volume43Issue:13Pages:2524-2529
ISSN0021-9290
AbstractStrong mechanical forces can, obviously, disrupt cell-cell and cell-matrix adhesions, e.g., cyclic uniaxial stretch induces instability of cell adhesion, which then causes the reorientation of cells away from the stretching direction. However, recent experiments also demonstrated the existence of force dependent adhesion growth (rather than dissociation). To provide a quantitative explanation for the two seemingly contradictory phenomena, a microscopic model that includes both integrin-integrin interaction and integrin-ligand interaction is developed at molecular level by treating the focal adhesion as an adhesion cluster. The integrin clustering dynamics and integrin-ligand binding dynamics are then simulated within one unified theoretical frame with Monte Carlo simulation. We find that the focal adhesion will grow when the traction force is higher than a relative small threshold value, and the growth is dominated by the reduction of local chemical potential energy by the traction force. In contrast, the focal adhesion will rupture when the traction force exceeds a second threshold value, and the rupture is dominated by the breaking of integrin-ligand bonds. Consistent with the experiments, these results suggest a force map for various responses of cell adhesion to different scales of mechanical force. PMID: 20542514
KeywordCell Adhesion Focal Adhesion Integrin Clustering Adhesion Growth Cell Reorientationintegrin–ligand Bonds
Subject Area生物力学
DOI10.1016/j.jbiomech.2010.05.019
Indexed BySCI
Language英语
WOS IDWOS:000282545900011
WOS KeywordCOUPLED CHEMICAL-REACTIONS ; SMOOTH-MUSCLE-CELLS ; ORIENTATION RESPONSE ; EXTRACELLULAR-MATRIX ; INTEGRIN LIGANDS ; DYNAMICS ; REORIENTATION ; CLUSTERS ; MECHANOSENSITIVITY ; ALIGNMENT
WOS Research AreaBiophysics ; Engineering
WOS SubjectBiophysics ; Engineering, Biomedical
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/42438
Collection非线性力学国家重点实验室
Corresponding AuthorDai LH(戴兰宏)
Recommended Citation
GB/T 7714
Kong D,Ji BH,Dai LH. Stabilizing to disruptive transition of focal adhesion response to mechanical forces[J]. Journal of Biomechanics,2010,43(13):2524-2529.
APA 孔冬,季葆华,&戴兰宏.(2010).Stabilizing to disruptive transition of focal adhesion response to mechanical forces.Journal of Biomechanics,43(13),2524-2529.
MLA 孔冬,et al."Stabilizing to disruptive transition of focal adhesion response to mechanical forces".Journal of Biomechanics 43.13(2010):2524-2529.
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