Stabilizing to disruptive transition of focal adhesion response to mechanical forces

doi:10.1016/j.jbiomech.2010.05.019

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	Stabilizing to disruptive transition of focal adhesion response to mechanical forces
	Kong D(孔冬); Ji BH(季葆华); Dai LH(戴兰宏)
发表期刊	Journal of Biomechanics
	2010-08-18
卷号	43 期号:13 页码:2524-2529
ISSN	0021-9290
摘要	Strong mechanical forces can, obviously, disrupt cell-cell and cell-matrix adhesions, e.g., cyclic uniaxial stretch induces instability of cell adhesion, which then causes the reorientation of cells away from the stretching direction. However, recent experiments also demonstrated the existence of force dependent adhesion growth (rather than dissociation). To provide a quantitative explanation for the two seemingly contradictory phenomena, a microscopic model that includes both integrin-integrin interaction and integrin-ligand interaction is developed at molecular level by treating the focal adhesion as an adhesion cluster. The integrin clustering dynamics and integrin-ligand binding dynamics are then simulated within one unified theoretical frame with Monte Carlo simulation. We find that the focal adhesion will grow when the traction force is higher than a relative small threshold value, and the growth is dominated by the reduction of local chemical potential energy by the traction force. In contrast, the focal adhesion will rupture when the traction force exceeds a second threshold value, and the rupture is dominated by the breaking of integrin-ligand bonds. Consistent with the experiments, these results suggest a force map for various responses of cell adhesion to different scales of mechanical force. PMID: 20542514
关键词	Cell Adhesion Focal Adhesion Integrin Clustering Adhesion Growth Cell Reorientationintegrin–ligand Bonds
学科领域	生物力学
DOI	10.1016/j.jbiomech.2010.05.019
收录类别	SCI
语种	英语
WOS记录号	WOS:000282545900011
关键词[WOS]	COUPLED CHEMICAL-REACTIONS ; SMOOTH-MUSCLE-CELLS ; ORIENTATION RESPONSE ; EXTRACELLULAR-MATRIX ; INTEGRIN LIGANDS ; DYNAMICS ; REORIENTATION ; CLUSTERS ; MECHANOSENSITIVITY ; ALIGNMENT
WOS研究方向	Biophysics ; Engineering
WOS类目	Biophysics ; Engineering, Biomedical
引用统计	被引频次：35[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/42438
专题	非线性力学国家重点实验室
通讯作者	Dai LH(戴兰宏)
推荐引用方式 GB/T 7714	Kong D,Ji BH,Dai LH. Stabilizing to disruptive transition of focal adhesion response to mechanical forces[J]. Journal of Biomechanics,2010,43,13,:2524-2529.
APA	孔冬,季葆华,&戴兰宏.(2010).Stabilizing to disruptive transition of focal adhesion response to mechanical forces.Journal of Biomechanics,43(13),2524-2529.
MLA	孔冬,et al."Stabilizing to disruptive transition of focal adhesion response to mechanical forces".Journal of Biomechanics 43.13(2010):2524-2529.

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