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Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells
Li H(李红); Chen J(陈娟); Zhang Y(章燕); Sun SJ(孙树津); Tao ZL(陶祖莱); Long M(龙勉); Long M
Source PublicationScience China-Life Sciences
2010
Volume53Issue:9Pages:1085-1091
ISSN1674-7305
AbstractAbsence of gravity or microgravity influences the cellular functions of bone forming osteoblasts. The underlying mechanism, however, of cellular sensing and responding to the gravity vector is poorly understood. This work quantified the impact of vector-directional gravity on the biological responses of Ros 17/2.8 cells grown on upward-, downward- or edge-on-oriented substrates. Cell morphology and nuclear translocation, cell proliferation and the cell cycle, and cytoskeletal reorganization were found to vary significantly in the three orientations. All of the responses were duration-dependent. These results provide a new insight into understanding how osteoblasts respond to static vector-directional gravity.
KeywordSubstrate Orientation Osteoblasts Cell Shape Cell Cycle Cytoskeleton Random Positioning Machine Microgravity Osteoblasts Space Spaceflight Adhesion Gravity Nuclei Flight
DOI10.1007/s11427-010-4057-6
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000282479500005
WOS KeywordRANDOM POSITIONING MACHINE ; MICROGRAVITY ; OSTEOBLASTS ; SPACE ; SPACEFLIGHT ; ADHESION ; GRAVITY ; NUCLEI ; FLIGHT
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS SubjectBiology
Funding OrganizationChinese Academy of Sciences [KJCX2-YW-L08] ; National Natural Science Foundation of China [30730032, 30730093] ; National Key Basic Research Foundation of China [2006CB910303] ; National High Technology Research and Development Program of China [2007AA02Z306]
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/43627
Collection国家微重力实验室
Corresponding AuthorLong M
Recommended Citation
GB/T 7714
Li H,Chen J,Zhang Y,et al. Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells[J]. Science China-Life Sciences,2010,53(9):1085-1091.
APA Li H.,陈娟.,章燕.,孙树津.,陶祖莱.,...&Long M.(2010).Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells.Science China-Life Sciences,53(9),1085-1091.
MLA Li H,et al."Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells".Science China-Life Sciences 53.9(2010):1085-1091.
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