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Dynamics of morphological changes for mitochondrial fission and fusion
Wang SQ(王世骐); Fu ZL(付长亮); Zhang Y(章燕); Chen Q; Long M(龙勉); Long M
2010
发表期刊Science China-Physics Mechanics & Astronomy
卷号53期号:4页码:680-689
ISSN1674-7348
摘要Mitochondria experience continuous fusion and fission in a living cell, but their dynamics remains poorly quantified. Here a theoretical model was developed, upon a simplified population balance equation (PBE), to predict the morphological changes induced by mitochondrial fission and fusion. Assuming that both fission and fusion events are statistically independent, the survival probability of mitochondria staying in the fission or fusion state was formulated as an exponentially-decayed function with time, which depended on the time-dependent distribution of the mitochondrial volume and the fission and fusion rates. Parametric analysis was done for two typical volume distributions. One was Gamma distribution and the other was Gaussian distribution, derived from the measurements of volume distribution for individual mitochondria in a living cell and purified mitochondria in vitro. The predictions indicated that the survival probability strongly depended on morphological changes of individual mitochondria and was inversely correlated to the fission and fusion rates. This work provided a new insight into quantifying the mitochondrial dynamics via monitoring the evolution of the mitochondrial volume.
DOI10.1007/s11433-010-0163-5
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收录类别SCI
语种英语
WOS记录号WOS:000276776100012
关键词[WOS]LIVING CELLS ; RETICULUM ; TRANSPORT
WOS研究方向Physics
WOS类目Physics, Multidisciplinary
项目资助者National Natural Science Foundation of China [30730032, 10332060] ; National Key Basic Research Foundation of China [2006CB910303] ; National High Technology Research and Development Program of China [2007AA02Z306] ; Chinese Academy of Sciences [KJCX2-YW-L08]
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文献类型期刊论文
条目标识符http://dspace.imech.ac.cn/handle/311007/43665
专题国家微重力实验室
通讯作者Long M
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Wang SQ,Fu ZL,Zhang Y,et al. Dynamics of morphological changes for mitochondrial fission and fusion[J]. Science China-Physics Mechanics & Astronomy,2010,53(4):680-689.
APA 王世骐,付长亮,章燕,Chen Q,龙勉,&Long M.(2010).Dynamics of morphological changes for mitochondrial fission and fusion.Science China-Physics Mechanics & Astronomy,53(4),680-689.
MLA 王世骐,et al."Dynamics of morphological changes for mitochondrial fission and fusion".Science China-Physics Mechanics & Astronomy 53.4(2010):680-689.
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