中国科学院力学研究所机构知识库
Advanced  
IMECH-IR  > 国家微重力实验室  > 期刊论文
Title:
Dynamics of morphological changes for mitochondrial fission and fusion
Author: Wang SQ(王世骐); Fu ZL(付长亮); Zhang Y(章燕); Chen Q; Long M(龙勉)
Source: Science China-Physics Mechanics & Astronomy
Issued Date: 2010
Volume: 53, Issue:4, Pages:680-689
Abstract: Mitochondria experience continuous fusion and fission in a living cell, but their dynamics remains poorly quantified. Here a theoretical model was developed, upon a simplified population balance equation (PBE), to predict the morphological changes induced by mitochondrial fission and fusion. Assuming that both fission and fusion events are statistically independent, the survival probability of mitochondria staying in the fission or fusion state was formulated as an exponentially-decayed function with time, which depended on the time-dependent distribution of the mitochondrial volume and the fission and fusion rates. Parametric analysis was done for two typical volume distributions. One was Gamma distribution and the other was Gaussian distribution, derived from the measurements of volume distribution for individual mitochondria in a living cell and purified mitochondria in vitro. The predictions indicated that the survival probability strongly depended on morphological changes of individual mitochondria and was inversely correlated to the fission and fusion rates. This work provided a new insight into quantifying the mitochondrial dynamics via monitoring the evolution of the mitochondrial volume.
Language: 英语
Indexed Type: SCI
Corresponding Author: Long M
Correspondent Email: mlong@imech.ac.cn
DOI: 10.1007/s11433-010-0163-5
Related URLs: 查看原文
DOC Type: Article
WOS Subject: Physics, Multidisciplinary
WOS Subject Extended: Physics
WOS Keyword Plus: LIVING CELLS ; RETICULUM ; TRANSPORT
WOS ID: WOS:000276776100012
ISSN: 1674-7348
Citation statistics:
Content Type: 期刊论文
URI: http://dspace.imech.ac.cn/handle/311007/43665
Appears in Collections:国家微重力实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
096.pdf(865KB)----开放获取--View Download

Recommended Citation:
Wang SQ,Fu ZL,Zhang Y,et al. Dynamics of morphological changes for mitochondrial fission and fusion[J]. Science China-Physics Mechanics & Astronomy,2010-01-01,53(4):680-689.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[王世骐]'s Articles
[付长亮]'s Articles
[章燕]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[王世骐]‘s Articles
[付长亮]‘s Articles
[章燕]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 096.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院力学研究所 - Feedback
Powered by CSpace