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PEGylated Phospholipid Membrane on Polymer Cushion and Its Interaction with Cholesterol
Zhang YB; Chen YY(陈艳艳); Jin G(靳刚)
Source PublicationLangmuir
2010
Volume26Issue:13Pages:11140-11144
ISSN0743-7463
AbstractBy employing poly(ethylene glycol) (PEG) shielding and a polymer cushion to achieve air stability of the lipid membrane, we have analyzed PEG influence on dried membranes and the interaction with cholesterol. Small unilamellar vesicles (SUVs) formed by the mixture of 1,2-dimyristoylphosphatidylcholine (DMPC) with different molar fraction of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(poly(ethylene glycol))-2000] (DSPE-PEG(2000)) adsorb and fuse into membranes on different polymer-modified silicon dioxide surfaces, including chitosan, poly(L-lysine) (PLL), and hyaluronic acid, Dried membranes arc further examined by ellipsometer and atomic force microscopy (AFM). Only chitosan can support a visible and uniform lipid array. The thickness of dry PEGylated lipid membrane is reduced gradually as the molar fraction of PEG increases. AFM scanning confirms the lipid membrane stacking for vesicles containing low PEG, and only a proper amount of PEG can maintain a single lipid hi lover; however, the air stability of the membrane will be destroyed if overloading. PEG. Cholesterol incorporation can greatly improve the structural stability of lipid membrane, especially for those containing high molar fraction of PEG. Different amounts of cholesterol influence the thickness and surface morphology of dried membrane.
DOI10.1021/la100973p
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Indexed BySCI
Language英语
WOS IDWOS:000279239900099
WOS KeywordCONDENSED COMPLEXES ; IMAGING ELLIPSOMETRY ; BILAYER-MEMBRANES ; MICROARRAYS ; MONOLAYER ; STABILITY ; RESONANCE ; SYSTEM ; LIPIDS ; FLUID
WOS Research AreaChemistry ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
Funding OrganizationMinistry of Science and Technology of China [2008AA02Z419] ; Natural Science Foundation of China [10804083, 20845003] ; Chinese Academy of Sciences [KJCX2. YW.M04] ; Key Laboratory of Microgravity, Institute of Mechanics, CAS
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Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/43695
Collection国家微重力实验室
Recommended Citation
GB/T 7714
Zhang YB,Chen YY,Jin G. PEGylated Phospholipid Membrane on Polymer Cushion and Its Interaction with Cholesterol[J]. Langmuir,2010,26(13):11140-11144.
APA Zhang YB,陈艳艳,&靳刚.(2010).PEGylated Phospholipid Membrane on Polymer Cushion and Its Interaction with Cholesterol.Langmuir,26(13),11140-11144.
MLA Zhang YB,et al."PEGylated Phospholipid Membrane on Polymer Cushion and Its Interaction with Cholesterol".Langmuir 26.13(2010):11140-11144.
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