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Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation
Shi XH(施兴华); von dem Bussche A; Hurt RH; Kane AB; Gao HJ(高华健); Shi, XH (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
Source PublicationNature Nanotechnology
2011
Volume6Issue:11Pages:714-719
ISSN1748-3387
AbstractMaterials with high aspect ratio, such as carbon nanotubes and asbestos fibres, have been shown to cause length-dependent toxicity in certain cells because these long materials prevent complete ingestion and this frustrates the cell(1-3). Biophysical models have been proposed to explain how spheres and elliptical nanostructures enter cells(4-8), but one-dimensional nanomaterials have not been examined. Here, we show experimentally and theoretically that cylindrical one-dimensional nanomaterials such as carbon nanotubes enter cells through the tip first. For nanotubes with end caps or carbon shells at their tips, uptake involves tip recognition through receptor binding, rotation that is driven by asymmetric elastic strain at the tube-bilayer interface, and near-vertical entry. The precise angle of entry is governed by the relative timescales for tube rotation and receptor diffusion. Nanotubes without caps or shells on their tips show a different mode of membrane interaction, posing an interesting question as to whether modifying the tips of tubes may help avoid frustrated uptake by cells.
KeywordWalled Carbon Nanotubes Receptor-mediated Endocytosis Asbestos Phagocytosis Nanoparticles Toxicity Inflammation Macrophages Crocidolite Responses
Subject AreaScience & Technology - Other Topics ; Materials Science
DOI10.1038/NNANO.2011.151
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000296737300009
WOS KeywordWALLED CARBON NANOTUBES ; RECEPTOR-MEDIATED ENDOCYTOSIS ; ASBESTOS ; PHAGOCYTOSIS ; NANOPARTICLES ; TOXICITY ; INFLAMMATION ; MACROPHAGES ; CROCIDOLITE ; RESPONSES
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationThis work was supported by the National Science Foundation (NSF; grant CMMI-1028530), the US Department of Commerce, National Institute of Standards and Technology as part of the Rhode Island Consortium for Nanoscience and Nanotechnology, the National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program P42 ES013660, and an R01 grant (ES016178) from the NIEHS. The simulations reported were performed on NSF TeraGrid resources provided by National Institute for Computational Sciences (NICS; under MCB090194) and resources from the Supercomputing Center of Chinese Academy of Sciences (SCCAS) and Shanghai Supercomputer Center (SSC). The authors thank P. Weston in the Molecular Pathology Core at Brown University for her assistance with electron microscopic sample preparation and imaging and F. Guo for measurement of MWCNT zeta potentials.
DepartmentLNM微结构计算力学(筹)
Classification一类
Citation statistics
Cited Times:280[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/44897
Collection非线性力学国家重点实验室
Corresponding AuthorShi, XH (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Shi XH,von dem Bussche A,Hurt RH,et al. Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation[J]. Nature Nanotechnology,2011,6(11):714-719.
APA 施兴华,von dem Bussche A,Hurt RH,Kane AB,高华健,&Shi, XH .(2011).Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation.Nature Nanotechnology,6(11),714-719.
MLA 施兴华,et al."Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation".Nature Nanotechnology 6.11(2011):714-719.
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