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Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review
Long M(龙勉); Sato M; Lim CT; Wu JH; Adachi T; Inoue Y; Long, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Ctr Biomech & Bioengn, Inst Mech, Beijing 100190, Peoples R China
2011
发表期刊Cellular and Molecular Bioengineering
卷号4期号:3页码:327-339
ISSN1865-5025
摘要Recent advances in micro- and nano-technologies and high-end computing have enabled the development of new experimental and modeling approaches to study biomechanics at the micro- and nano-scales that were previously not possible. These new cutting-edge approaches are contributing toward our understanding in emerging areas such as mechanobiology and mechanochemistry. Another important potential contribution lies in translational medicine, since biomechanical studies at the cellular and molecular levels have direct relevance in areas such disease diagnosis, nano-medicine and drug delivery. Thus, the developed experimental and modeling approaches are critical in elucidating important mechanistic insights in both basic sciences and clinical treatment. While it is hard to cover all the recent advances in this mini-review, we focus on several important approaches. For experimental techniques, we review the assays involving shear flow, cellular imaging, microbead, microcontact printing, and micropillars at the micro-scale, and micropipette aspiration, optical tweezers, parallel flow chamber, and atomic force microscopy at the nano-scale. In modeling and simulations, we outline the theoretical modeling for actin dynamics in migrating cell and actin-based cell motility in cellular mechanics, as well as the receptor-ligand binding in cell adhesion and the application of free, steered, and flow molecular dynamics simulations in molecular biomechanics. Relevant scientific issues and applications are also discussed.
关键词Cellular Mechanics Molecular Biomechanics Experimental Techniques Theoretical Modeling Computations Fluid Shear-stress Endothelial-cell Proliferation Adhesive Dynamics Simulation Ligand Binding-kinetics Glycoprotein-ib-alpha Von-willebrand-factor Molecular-dynamics Mechanical-stress Beta-switch 2-dimensional Kinetics
学科领域Cell Biology ; Biophysics
DOI10.1007/s12195-011-0183-x
URL查看原文
收录类别SCI
语种英语
WOS记录号WOS:000297866300002
关键词[WOS]FLUID SHEAR-STRESS ; ENDOTHELIAL-CELL PROLIFERATION ; ADHESIVE DYNAMICS SIMULATION ; LIGAND BINDING-KINETICS ; GLYCOPROTEIN-IB-ALPHA ; VON-WILLEBRAND-FACTOR ; MOLECULAR-DYNAMICS ; MECHANICAL-STRESS ; BETA-SWITCH ; 2-DIMENSIONAL KINETICS
WOS研究方向Cell Biology ; Biophysics
WOS类目Cell & Tissue Engineering ; Biophysics ; Cell Biology
课题组名称NML分子-细胞生物力学与空间生命科学
论文分区Q4
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://dspace.imech.ac.cn/handle/311007/45074
专题国家微重力实验室
通讯作者Long, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Ctr Biomech & Bioengn, Inst Mech, Beijing 100190, Peoples R China
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GB/T 7714
Long M,Sato M,Lim CT,et al. Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review[J]. Cellular and Molecular Bioengineering,2011,4(3):327-339.
APA 龙勉.,Sato M.,Lim CT.,Wu JH.,Adachi T.,...&Long, M .(2011).Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review.Cellular and Molecular Bioengineering,4(3),327-339.
MLA 龙勉,et al."Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review".Cellular and Molecular Bioengineering 4.3(2011):327-339.
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