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Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review
Long M(龙勉); Sato M; Lim CT; Wu JH; Adachi T; Inoue Y; Long, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Ctr Biomech & Bioengn, Inst Mech, Beijing 100190, Peoples R China
Source PublicationCellular and Molecular Bioengineering
2011
Volume4Issue:3Pages:327-339
ISSN1865-5025
AbstractRecent advances in micro- and nano-technologies and high-end computing have enabled the development of new experimental and modeling approaches to study biomechanics at the micro- and nano-scales that were previously not possible. These new cutting-edge approaches are contributing toward our understanding in emerging areas such as mechanobiology and mechanochemistry. Another important potential contribution lies in translational medicine, since biomechanical studies at the cellular and molecular levels have direct relevance in areas such disease diagnosis, nano-medicine and drug delivery. Thus, the developed experimental and modeling approaches are critical in elucidating important mechanistic insights in both basic sciences and clinical treatment. While it is hard to cover all the recent advances in this mini-review, we focus on several important approaches. For experimental techniques, we review the assays involving shear flow, cellular imaging, microbead, microcontact printing, and micropillars at the micro-scale, and micropipette aspiration, optical tweezers, parallel flow chamber, and atomic force microscopy at the nano-scale. In modeling and simulations, we outline the theoretical modeling for actin dynamics in migrating cell and actin-based cell motility in cellular mechanics, as well as the receptor-ligand binding in cell adhesion and the application of free, steered, and flow molecular dynamics simulations in molecular biomechanics. Relevant scientific issues and applications are also discussed.
KeywordCellular Mechanics Molecular Biomechanics Experimental Techniques Theoretical Modeling Computations Fluid Shear-stress Endothelial-cell Proliferation Adhesive Dynamics Simulation Ligand Binding-kinetics Glycoprotein-ib-alpha Von-willebrand-factor Molecular-dynamics Mechanical-stress Beta-switch 2-dimensional Kinetics
Subject AreaCell Biology ; Biophysics
DOI10.1007/s12195-011-0183-x
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000297866300002
WOS KeywordFLUID SHEAR-STRESS ; ENDOTHELIAL-CELL PROLIFERATION ; ADHESIVE DYNAMICS SIMULATION ; LIGAND BINDING-KINETICS ; GLYCOPROTEIN-IB-ALPHA ; VON-WILLEBRAND-FACTOR ; MOLECULAR-DYNAMICS ; MECHANICAL-STRESS ; BETA-SWITCH ; 2-DIMENSIONAL KINETICS
WOS Research AreaCell Biology ; Biophysics
WOS SubjectCell & Tissue Engineering ; Biophysics ; Cell Biology
DepartmentNML分子-细胞生物力学与空间生命科学
ClassificationQ4
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/45074
Collection国家微重力实验室
Corresponding AuthorLong, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Ctr Biomech & Bioengn, Inst Mech, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Long M,Sato M,Lim CT,et al. Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review[J]. Cellular and Molecular Bioengineering,2011,4(3):327-339.
APA 龙勉.,Sato M.,Lim CT.,Wu JH.,Adachi T.,...&Long, M .(2011).Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review.Cellular and Molecular Bioengineering,4(3),327-339.
MLA 龙勉,et al."Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review".Cellular and Molecular Bioengineering 4.3(2011):327-339.
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