| Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review |
| Long M(龙勉) ; Sato M; Lim CT; Wu JH; Adachi T; Inoue Y; Long, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Ctr Biomech & Bioengn, Inst Mech, Beijing 100190, Peoples R China
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| 发表期刊 | Cellular and Molecular Bioengineering
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| 2011
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| 卷号 | 4期号:3页码:327-339 |
| ISSN | 1865-5025
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| 摘要 | Recent advances in micro- and nano-technologies and high-end computing have enabled the development of new experimental and modeling approaches to study biomechanics at the micro- and nano-scales that were previously not possible. These new cutting-edge approaches are contributing toward our understanding in emerging areas such as mechanobiology and mechanochemistry. Another important potential contribution lies in translational medicine, since biomechanical studies at the cellular and molecular levels have direct relevance in areas such disease diagnosis, nano-medicine and drug delivery. Thus, the developed experimental and modeling approaches are critical in elucidating important mechanistic insights in both basic sciences and clinical treatment. While it is hard to cover all the recent advances in this mini-review, we focus on several important approaches. For experimental techniques, we review the assays involving shear flow, cellular imaging, microbead, microcontact printing, and micropillars at the micro-scale, and micropipette aspiration, optical tweezers, parallel flow chamber, and atomic force microscopy at the nano-scale. In modeling and simulations, we outline the theoretical modeling for actin dynamics in migrating cell and actin-based cell motility in cellular mechanics, as well as the receptor-ligand binding in cell adhesion and the application of free, steered, and flow molecular dynamics simulations in molecular biomechanics. Relevant scientific issues and applications are also discussed. |
| 关键词 | Cellular Mechanics
Molecular Biomechanics
Experimental Techniques
Theoretical Modeling
Computations
Fluid Shear-stress
Endothelial-cell Proliferation
Adhesive Dynamics Simulation
Ligand Binding-kinetics
Glycoprotein-ib-alpha
Von-willebrand-factor
Molecular-dynamics
Mechanical-stress
Beta-switch
2-dimensional Kinetics
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| 学科领域 | Cell Biology
; Biophysics
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| DOI | 10.1007/s12195-011-0183-x
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| URL | 查看原文
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| 收录类别 | SCI
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| 语种 | 英语
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| WOS记录号 | WOS:000297866300002
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| 关键词[WOS] | FLUID SHEAR-STRESS
; ENDOTHELIAL-CELL PROLIFERATION
; ADHESIVE DYNAMICS SIMULATION
; LIGAND BINDING-KINETICS
; GLYCOPROTEIN-IB-ALPHA
; VON-WILLEBRAND-FACTOR
; MOLECULAR-DYNAMICS
; MECHANICAL-STRESS
; BETA-SWITCH
; 2-DIMENSIONAL KINETICS
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| WOS研究方向 | Cell Biology
; Biophysics
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| WOS类目 | Cell & Tissue Engineering
; Biophysics
; Cell Biology
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| 课题组名称 | NML分子-细胞生物力学与空间生命科学
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| 论文分区 | Q4
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| 引用统计 |
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| 文献类型 | 期刊论文
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| 条目标识符 | http://dspace.imech.ac.cn/handle/311007/45074
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| 专题 | 微重力重点实验室
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| 通讯作者 | Long, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Ctr Biomech & Bioengn, Inst Mech, Beijing 100190, Peoples R China |
推荐引用方式
GB/T 7714 |
Long M,Sato M,Lim CT,et al. Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review[J]. Cellular and Molecular Bioengineering,2011,4,3,:327-339.
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| APA |
龙勉.,Sato M.,Lim CT.,Wu JH.,Adachi T.,...&Long, M .(2011).Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review.Cellular and Molecular Bioengineering,4(3),327-339.
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| MLA |
龙勉,et al."Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review".Cellular and Molecular Bioengineering 4.3(2011):327-339.
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