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Title: Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review
Author: Long M(龙勉); Sato M; Lim CT; Wu JH; Adachi T; Inoue Y
Source: Cellular and Molecular Bioengineering
Issued Date: 2011
Volume: 4, Issue:3, Pages:327-339
Abstract: Recent advances in micro- and nano-technologies and high-end computing have enabled the development of new experimental and modeling approaches to study biomechanics at the micro- and nano-scales that were previously not possible. These new cutting-edge approaches are contributing toward our understanding in emerging areas such as mechanobiology and mechanochemistry. Another important potential contribution lies in translational medicine, since biomechanical studies at the cellular and molecular levels have direct relevance in areas such disease diagnosis, nano-medicine and drug delivery. Thus, the developed experimental and modeling approaches are critical in elucidating important mechanistic insights in both basic sciences and clinical treatment. While it is hard to cover all the recent advances in this mini-review, we focus on several important approaches. For experimental techniques, we review the assays involving shear flow, cellular imaging, microbead, microcontact printing, and micropillars at the micro-scale, and micropipette aspiration, optical tweezers, parallel flow chamber, and atomic force microscopy at the nano-scale. In modeling and simulations, we outline the theoretical modeling for actin dynamics in migrating cell and actin-based cell motility in cellular mechanics, as well as the receptor-ligand binding in cell adhesion and the application of free, steered, and flow molecular dynamics simulations in molecular biomechanics. Relevant scientific issues and applications are also discussed.
Keyword: Cellular Mechanics ; Molecular Biomechanics ; Experimental Techniques ; Theoretical Modeling ; Computations ; Fluid Shear-Stress ; Endothelial-Cell Proliferation ; Adhesive Dynamics Simulation ; Ligand Binding-Kinetics ; Glycoprotein-Ib-Alpha ; Von-Willebrand-Factor ; Molecular-Dynamics ; Mechanical-Stress ; Beta-Switch ; 2-Dimensional Kinetics
Language: 英语
Indexed Type: SCI
Corresponding Author: Long, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Ctr Biomech & Bioengn, Inst Mech, Beijing 100190, Peoples R China
Correspondent Email: mlong@imech.ac.cn; sato@bml.mech.tohoku.ac.jp; ctlim@nus.edu.sg
DOI: 10.1007/s12195-011-0183-x
Related URLs: 查看原文
DOC Type: Review
WOS Subject: Cell & Tissue Engineering ; Biophysics ; Cell Biology
WOS Subject Extended: Cell Biology ; Biophysics
WOS Keyword Plus: FLUID SHEAR-STRESS ; ENDOTHELIAL-CELL PROLIFERATION ; ADHESIVE DYNAMICS SIMULATION ; LIGAND BINDING-KINETICS ; GLYCOPROTEIN-IB-ALPHA ; VON-WILLEBRAND-FACTOR ; MOLECULAR-DYNAMICS ; MECHANICAL-STRESS ; BETA-SWITCH ; 2-DIMENSIONAL KINETICS
WOS ID: WOS:000297866300002
ISSN: 1865-5025
Rank: [Long, Mian] Chinese Acad Sci, Key Lab Micrograv, Ctr Biomech & Bioengn, Inst Mech, Beijing 100190, Peoples R China; [Sato, Masaaki] Tohoku Univ, Grad Sch Biomed Engn, Sendai, Miyagi 9808579, Japan; [Lim, Chwee Teck] Natl Univ Singapore, Div Bioengn, Dept Mech Engn, Mechanobiol Inst, Singapore 117576, Singapore; [Wu, Jianhua] S China Univ Technol, Inst Biomech, Sch Biosci & Bioengn, Guangzhou, Guangdong, Peoples R China; [Adachi, Taiji; Inoue, Yasuhiro] Kyoto Univ, Inst Frontier Med Sci, Kyoto, Japan
Subject: Cell Biology; Biophysics
Department: NML分子-细胞生物力学与空间生命科学
Classification: Q4
Citation statistics:
Content Type: 期刊论文
URI: http://dspace.imech.ac.cn/handle/311007/45074
Appears in Collections:国家微重力实验室_期刊论文

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龙勉;Sato M;Lim CT;Wu JH;Adachi T;Inoue Y.Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review,CELLULAR AND MOLECULAR BIOENGINEERING,2011,4(3):327-339
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