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Title: Fluid Dynamics Analysis of a Novel Micropatterned Cell Bioreactor
Author: Cui YH; Huo B(霍波); Sun SJ(孙树津); Yang F(杨帆); Gao YX(高宇欣); Pan J; Long M(龙勉)
Source: Annals of Biomedical Engineering
Issued Date: 2011
Volume: 39, Issue:5, Pages:1592-1605
Abstract: Although flow-based bioreactor has been widely used to provide sufficient mass transportation and nutrient supply for cell proliferation, differentiation, and apoptosis, the underlying mechanism of cell responses to applied flow at single cell level remains unclear. This study has developed a novel bioreactor that combines flow bioreactor with microfabrication technique to isolate individual cells onto micropatterned substrate. A mechanical model has also been developed to quantify the flow field or the microenvironment around the single cell; flow dynamics has been analyzed on five geometrically different patterns of circle-, cube-, 1:2 ellipse-, 1:3 ellipse-, and rectangle-shaped "virtual cells." The results of this study have demonstrated that the flow field is highly pattern dependent, and all the hydrodynamic development length, cell spacing, and orientation of inlet velocity vector are crucial for maintaining a fully developed flow. This study has provided a theoretical basis for optimizing the design of micropatterned flow bioreactor and a novel approach to understand the cell mechanotransduction and cell-surface interaction at single cell level.
Keyword: Fluid Dynamics ; Cell Bioreactor ; Micropattern ; Steady Shear-Stress ; Endothelial-Cells ; Flow ; Mechanotransduction ; Environment ; Prediction ; Scaffolds ; Adhesion ; Chamber ; Systems
Language: 英语
Indexed Type: SCI ; EI
Corresponding Author: Long, MA (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Beijing 100190, Peoples R China
Correspondent Email: mlong@imech.ac.cn
DOI: 10.1007/s10439-011-0250-4
Related URLs: 查看原文
DOC Type: Article
WOS Subject: Engineering, Biomedical
WOS Subject Extended: Engineering
WOS Keyword Plus: STEADY SHEAR-STRESS ; ENDOTHELIAL-CELLS ; FLOW ; MECHANOTRANSDUCTION ; ENVIRONMENT ; PREDICTION ; SCAFFOLDS ; ADHESION ; CHAMBER ; SYSTEMS
WOS ID: WOS:000289243100020
ISSN: 0090-6964
Rank: [Huo, Bo; Sun, Shujin; Yang, Fan; Gao, Yuxin; Long, Mian] Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Beijing 100190, Peoples R China; [Cui, Yuhong] Tianjin Univ, Dept Mech, Tianjin 300072, Peoples R China; [Huo, Bo; Sun, Shujin; Yang, Fan; Gao, Yuxin; Long, Mian] Natl Micrograv Lab, Beijing 100190, Peoples R China; [Huo, Bo; Sun, Shujin; Yang, Fan; Gao, Yuxin; Long, Mian] Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China; [Pan, Jun] Chongqing Univ, Bioengn Coll, Chongqing 400030, Peoples R China
Subject: Engineering
Department: NML分子-细胞生物力学与空间生命科学
Classification: 二类/Q2
Citation statistics:
Content Type: 期刊论文
URI: http://dspace.imech.ac.cn/handle/311007/45086
Appears in Collections:国家微重力实验室_期刊论文

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Recommended Citation:
Cui YH;霍波;孙树津;杨帆;高宇欣;Pan J;龙勉.Fluid Dynamics Analysis of a Novel Micropatterned Cell Bioreactor,ANNALS OF BIOMEDICAL ENGINEERING,2011,39(5):1592-1605
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