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Development of biosensor based on imaging ellipsometry and biomedical applications
Jin G(靳刚); Meng YH(孟永宏); Liu L(刘丽); Niu Y(牛宇); Chen S(陈涉); Cai Q; Jiang TJ; Jin, G (reprint author), Chinese Acad Sci, NML, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China
Source PublicationThin Solid Films
2011
Volume519Issue:9Pages:2750-2757
ISSN0040-6090
AbstractSo far, combined with a microfluidic reactor array system, an engineering system of biosensor based on imaging ellipsometry is installed for biomedical applications, such as antibody screen, hepatitis B markers detection, cancer markers spectrum and virus recognition, etc. Furthermore, the biosensor in total internal reflection (TIR) mode has be improved by a spectroscopic light, optimization settings of polarization and low noise CCD which brings an obvious improvement of 10 time increase in the sensitivity and SNR, and 50 times lower concentration in the detection limit with a throughput of 48 independent channels and the time resolution of 0.04 S. (C) 2010 Elsevier B.V. All rights reserved.
KeywordImaging Ellipsometry Biosensor Protein Microarray Total Internal Reflection Off-null Ellipsometry Optical Protein-chip Optimization Visualization
Subject AreaMaterials Science ; Physics
DOI10.1016/j.tsf.2010.12.175
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000289174200040
WOS KeywordOFF-NULL ELLIPSOMETRY ; OPTICAL PROTEIN-CHIP ; OPTIMIZATION ; VISUALIZATION
WOS Research AreaMaterials Science ; Physics
WOS SubjectMaterials Science, Multidisciplinary ; Materials Science, Coatings & Films ; Physics, Applied ; Physics, Condensed Matter
DepartmentNML纳米生物光学
Classification二类/Q2
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/45099
Collection国家微重力实验室
Corresponding AuthorJin, G (reprint author), Chinese Acad Sci, NML, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Jin G,Meng YH,Liu L,et al. Development of biosensor based on imaging ellipsometry and biomedical applications[J]. Thin Solid Films,2011,519(9):2750-2757.
APA Jin G.,Meng YH.,Liu L.,Niu Y.,Chen S.,...&Jin, G .(2011).Development of biosensor based on imaging ellipsometry and biomedical applications.Thin Solid Films,519(9),2750-2757.
MLA Jin G,et al."Development of biosensor based on imaging ellipsometry and biomedical applications".Thin Solid Films 519.9(2011):2750-2757.
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