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Improvement for sensitivity of biosensor with total internal reflection imaging ellipsometry (TIRIE)
Liu L(刘丽); Chen YY(陈艳艳); Meng YH(孟永宏); Chen S(陈涉); Jin G(靳刚); Jin, G (reprint author), Chinese Acad Sci, Natl Micrograv Lab, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China
Source PublicationThin Solid Films
2011
Volume519Issue:9Pages:2758-2762
ISSN0040-6090
AbstractThe biosensor based on the total internal reflection imaging ellipsometry (TIRIE) is realized as an automatic analysis method for protein interaction processes in real-time, with high throughput and label-free. An evanescent wave is used as the optical probe to monitor bio-molecular interactions on a chip surface with a high sensitivity due to its phase sensitive property. In this paper, the technique is optimized with a polarization setting, a spectroscopic light source and a low noise CCD detector to improve the performance of the biosensor in sensitivity and detection limit, as evidenced by a quantitative detection of Hepatitis B virus surface antigen (HbsAg) with concentrations of 8, 16, 32, 64, 125 and 250 ng/ml. The sensitivity is increased by one order of magnitude and the detection limit has been extended more than 50 times for HbsAg detection. (C) 2011 Elsevier B.V. All rights reserved.
KeywordSensitivity Improvement Imaging Ellipsometry Total Internal Reflection Biosensor Hbsag Detection Plasmon Enhanced Ellipsometry Surface Resonance Sensors
Subject AreaMaterials Science ; Physics
DOI10.1016/j.tsf.2010.12.130
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000289174200041
WOS KeywordPLASMON ENHANCED ELLIPSOMETRY ; SURFACE ; RESONANCE ; SENSORS
WOS Research AreaMaterials Science ; Physics
WOS SubjectMaterials Science, Multidisciplinary ; Materials Science, Coatings & Films ; Physics, Applied ; Physics, Condensed Matter
DepartmentNML纳米生物光学
Classification二类/Q2
Citation statistics
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/45100
Collection国家微重力实验室
Corresponding AuthorJin, G (reprint author), Chinese Acad Sci, Natl Micrograv Lab, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Liu L,Chen YY,Meng YH,et al. Improvement for sensitivity of biosensor with total internal reflection imaging ellipsometry (TIRIE)[J]. Thin Solid Films,2011,519(9):2758-2762.
APA Liu L,Chen YY,Meng YH,Chen S,Jin G,&Jin, G .(2011).Improvement for sensitivity of biosensor with total internal reflection imaging ellipsometry (TIRIE).Thin Solid Films,519(9),2758-2762.
MLA Liu L,et al."Improvement for sensitivity of biosensor with total internal reflection imaging ellipsometry (TIRIE)".Thin Solid Films 519.9(2011):2758-2762.
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