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Alternative TitleAdvances of mechanical stimulation-induced calcium response and transfer in osteoblasts
霍波; 康英永; 胡漫; 李平
Source Publication医用生物力学
Other AbstractCalcium is not only the important signaling molecule within and between bone cells,but also the primary component of extracellular matrix in bone.It has been demonstrated during the past over 100 years that mechanical stimulations can regulate the molecular signal transduction and intercellular communication in bone cells as well as the bone mineralization and resorption at tissue level,but further more researches are still needed to give insight into the mechanism of mechanical stimulation-induced bone remodeling.This paper will summarize the related works on the following aspects:(1) the primary experimental approaches for studying mechanical stimulation-induced calcium response and transfer in osteoblasts,(2) the calcium sources and mechanism of calcium response in osteoblasts,(3) the intercellular calcium transfer pathways and(4) characteristic parameters of calcium response and transfer in osteoblasts.Finally,several potential research directions in this field are presented in the paper.
Keyword成骨细胞 钙响应 钙传递 力学刺激 信号转导
Subject Area力学
Indexed ByEI ; CSCD
Funding Organization国家自然科学基金委面上项目(30970707);科技部国家高技术研究发展计划(863计划)项目(2009AA02Z407)的支持
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Document Type期刊论文
Corresponding Author霍波
Recommended Citation
GB/T 7714
霍波,康英永,胡漫,等. 成骨细胞力致钙响应和钙传递的研究进展[J]. 医用生物力学,2011,26(4):382-388.
APA 霍波,康英永,胡漫,&李平.(2011).成骨细胞力致钙响应和钙传递的研究进展.医用生物力学,26(4),382-388.
MLA 霍波,et al."成骨细胞力致钙响应和钙传递的研究进展".医用生物力学 26.4(2011):382-388.
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