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Development of biosensor based on imaging ellipsometry and biomedical applications
Jin G(靳刚); Meng YH(孟永宏); Liu L(刘丽); Niu Y(牛宇); Chen S(陈涉); Cai Q; Jiang TJ; Jin, G (reprint author), Chinese Acad Sci, NML, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China
Source PublicationTHIN SOLID FILMS
2011
Pages2750-2757
Conference Name5th International Conference on Spectroscopic Ellipsometry
Conference DateMAY 23-29, 2010
Conference PlaceAlbany, NY
AbstractSo far, combined with a microfluidic reactor array system, an engineering system of biosensor based on imaging ellipsometry is installed for biomedical applications, such as antibody screen, hepatitis B markers detection, cancer markers spectrum and virus recognition, etc. Furthermore, the biosensor in total internal reflection (TIR) mode has be improved by a spectroscopic light, optimization settings of polarization and low noise CCD which brings an obvious improvement of 10 time increase in the sensitivity and SNR, and 50 times lower concentration in the detection limit with a throughput of 48 independent channels and the time resolution of 0.04 S. (C) 2010 Elsevier B.V. All rights reserved.
KeywordImaging Ellipsometry Biosensor Protein Microarray Total Internal Reflection Off-null Ellipsometry Optical Protein-chip Optimization Visualization
Department中科院国家微重力实验室
Funding OrganizationUniv Albany, Coll Nanoscale & Engn
URL查看原文
Language英语
Document Type会议论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/45317
Collection国家微重力实验室
Corresponding AuthorJin, G (reprint author), Chinese Acad Sci, NML, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Jin G,Meng YH,Liu L,et al. Development of biosensor based on imaging ellipsometry and biomedical applications[C]. PO BOX 564, 1001 LAUSANNE, SWITZERLAND:ELSEVIER SCIENCE SA,2011:2750-2757.
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