| Total internal reflection imaging ellipsometry (TIRIE) biosensor sensitivity improvement with low noise imaging device | |
Liu L(刘丽) ; Jin G(靳刚); Jin, G (reprint author), Chinese Acad Sci, NML, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China
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| 会议录名称 | SENSORS, CAMERAS, AND SYSTEMS FOR INDUSTRIAL, SCIENTIFIC, AND CONSUMER APPLICATIONS XII |
| 2011 | |
| 页码 | 78750U |
| 会议名称 | Conference on Sensors, Cameras, and Systems for Industrial, Scientific, and Consumer Applications XII |
| 会议日期 | JAN 25-27, 2011 |
| 会议地点 | San Francisco, CA |
| 摘要 | The biosensors with properties of real-time, high throughput and label-free are more and more popular recently, in which the biosensor based on the total internal reflection imaging ellipsometry (TIRIE) is a novel imaging detector for protein interaction processes. In previous work, three techniques are introduced to improve the performance of the biosensor including polarization setting optimization, spectroscopic light source application and low noise CCD detector adoption. In this paper, the effect of the low noise CCD detector technology on the sensitivity and detection limit improvement is analyzed. An obvious improvement of 10 time increase in the sensitivity and SNR, and 50 times lower concentration in the detection limit is obtained by optimization. |
| 关键词 | Total Internal Reflection Imaging Ellipsometry Biosensor |
| 课题组名称 | NML纳米生物光学 |
| ISBN号 | 978-0-8194-8412-3 |
| URL | 查看原文 |
| 收录类别 | CPCI |
| 语种 | 英语 |
| 文献类型 | 会议论文 |
| 条目标识符 | http://dspace.imech.ac.cn/handle/311007/45327 |
| 专题 | 微重力重点实验室 |
| 通讯作者 | Jin, G (reprint author), Chinese Acad Sci, NML, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu L,Jin G,Jin, G . Total internal reflection imaging ellipsometry (TIRIE) biosensor sensitivity improvement with low noise imaging device[C]SENSORS, CAMERAS, AND SYSTEMS FOR INDUSTRIAL, SCIENTIFIC, AND CONSUMER APPLICATIONS XII,2011:78750U. |
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| Conf2011-098.pdf（866KB） | 开放获取 | -- | 浏览 请求全文 | |||
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