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Total internal reflection imaging ellipsometry (TIRIE) biosensor sensitivity improvement with low noise imaging device
Liu L(刘丽); Jin G(靳刚); Jin, G (reprint author), Chinese Acad Sci, NML, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China
Source PublicationSENSORS, CAMERAS, AND SYSTEMS FOR INDUSTRIAL, SCIENTIFIC, AND CONSUMER APPLICATIONS XII
2011
Pages78750U
Conference NameConference on Sensors, Cameras, and Systems for Industrial, Scientific, and Consumer Applications XII
Conference DateJAN 25-27, 2011
Conference PlaceSan Francisco, CA
AbstractThe biosensors with properties of real-time, high throughput and label-free are more and more popular recently, in which the biosensor based on the total internal reflection imaging ellipsometry (TIRIE) is a novel imaging detector for protein interaction processes. In previous work, three techniques are introduced to improve the performance of the biosensor including polarization setting optimization, spectroscopic light source application and low noise CCD detector adoption. In this paper, the effect of the low noise CCD detector technology on the sensitivity and detection limit improvement is analyzed. An obvious improvement of 10 time increase in the sensitivity and SNR, and 50 times lower concentration in the detection limit is obtained by optimization.
KeywordTotal Internal Reflection Imaging Ellipsometry Biosensor
DepartmentNML纳米生物光学
ISBN978-0-8194-8412-3
URL查看原文
Indexed ByCPCI
Language英语
Document Type会议论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/45327
Collection国家微重力实验室
Corresponding AuthorJin, G (reprint author), Chinese Acad Sci, NML, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Liu L,Jin G,Jin, G . Total internal reflection imaging ellipsometry (TIRIE) biosensor sensitivity improvement with low noise imaging device[C]SENSORS, CAMERAS, AND SYSTEMS FOR INDUSTRIAL, SCIENTIFIC, AND CONSUMER APPLICATIONS XII,2011:78750U.
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