IMECH-IR  > 国家微重力实验室
Alternative TitleMathematic model of respiratory mechanics based on monitored physiological parameters
霍波; 付瑞荣; 梁晨; 刁俊; 陶祖莱
Source Publication医用生物力学
Other AbstractObjective: To establish a model of respiratory mechanics with consideration of gas exchange and directly correlate with the gas content in blood during mechanical ventilation with the mechanics of respiratory system. Methods: By coupling the physiological parameters of respiratory system and blood circulation system, including the molecular numbers of oxygen and carbon dioxide in alveoli and clinically monitored physiological parameters such as gas content, hemoglobin content, heart rate and cardiac output, a mechanical model was constructed to predict those dynamic parameters of gas content, pressure and flow rate in airway and alveoli in continuous breathing cycles. Results: The gas content in different locations of a respiratory system was estimated by the model and the sensitivity of gas content in expiration to the undetermined parameters was evaluated. Conclusions: The model of respiratory mechanics developed in the study is a preliminary attempt to predict the regulation roles of physiological parameters clinically monitored during mechanical ventilation, which will provide a theoretical support for the design and development of novel respirators in the follow-up experiment.
Keyword呼吸力学 气血交换 机械通气 呼吸机 生理监护参数
Subject Area生物力学
Indexed ByCSCD ; EI
Funding Organization科技部国家高技术研究发展计划(863计划)资助项目(2009AA02Z407); 国家自然科学基金资助项目(30970707)
Citation statistics
Cited Times:2[CSCD]   [CSCD Record]
Document Type期刊论文
Corresponding Author霍波
Recommended Citation
GB/T 7714
霍波,付瑞荣,梁晨,等. 建立基于个体生理监护信息的呼吸力学模型[J]. 医用生物力学,2012,27(4):409-415.
APA 霍波,付瑞荣,梁晨,刁俊,&陶祖莱.(2012).建立基于个体生理监护信息的呼吸力学模型.医用生物力学,27(4),409-415.
MLA 霍波,et al."建立基于个体生理监护信息的呼吸力学模型".医用生物力学 27.4(2012):409-415.
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