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双亲性氧化石墨烯的合成及生物相容性
Alternative TitleSynthesis and Biocompatibility of Amphiphilic Graphene Oxide
李宁; 张琦; 张庆庆; 宋琴; 齐琳; 王龙; 唐明亮; 靳刚; 程国胜
Source Publication高等学校化学学报
2013-01-10
Volume34Issue:1Pages:50-54
ISSN0251-0790
Abstract以六亚甲基二异氰酸酯(HMDI)为偶联剂,通过与氧化石墨烯(GO)中的羧基或羟基反应,形成酰胺键或氨基甲酸酯键活化GO,然后与TWEEN 80中的羟基反应,将双亲性TWEEN分子偶联于GO表面,制备了双亲性GO.所制备的TWEEN 80接枝GO在水、氯仿和己烷等溶剂中均可稳定分散.以PC12及HeLa细胞为细胞模型,考察TWEEN 80接枝GO所制薄膜的细胞毒性,形态学观察及细胞活性检测(Calcein AM & EthD-1荧光染色及MTT检测)结果表明其具有良好的生物相容性.
Other AbstractAmphiphilic functionalization of graphene oxide(GO) is of the essence for its biomedical applications. TWEEN 80-grafted GO was synthesized by a two-step approach. In step 1, GO surface was activated with hexamethylene diisocyanate(HMDI) through a reaction between GO carboxyl or hydroxyl groups and isocyanate. HMDI-activated GO was then grafted by TWEEN 80 in step 2, resulting in amphiphilic GO nanosheets. The fabricated TWEEN 80-grafted GO exhibited excellent dispersibility in various solvents, such as water, chloroform and n-hexane. Furthermore, PC12 and HeLa cells were cultured on TWEEN 80-grafted GO film to assess its cytotoxicity. Cell morphology analysis and cell viability assay(Calcein AM &EthD-1 staining and MTT assay) indicated that the as-synthesized amphiphilic GO had good biocompatibility.
Keyword双亲性氧化石墨烯 生物相容性 Tween 80 六亚甲基二异氰酸酯
Subject Area交叉与边缘领域的力学
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Indexed ByEI ; CSCD
Language中文
WOS IDWOS:000317085300007
Funding Organization国家自然科学基金青年科学基金(批准号:31101059)资助
CSCD IDCSCD:4742797
DepartmentNML纳米生物光学
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/47014
Collection国家微重力实验室
Corresponding Author程国胜
Recommended Citation
GB/T 7714
李宁,张琦,张庆庆,等. 双亲性氧化石墨烯的合成及生物相容性[J]. 高等学校化学学报,2013,34(1):50-54.
APA 李宁.,张琦.,张庆庆.,宋琴.,齐琳.,...&程国胜.(2013).双亲性氧化石墨烯的合成及生物相容性.高等学校化学学报,34(1),50-54.
MLA 李宁,et al."双亲性氧化石墨烯的合成及生物相容性".高等学校化学学报 34.1(2013):50-54.
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