IMECH-IR  > 非线性力学国家重点实验室
Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels
Sun JS; Liu C(刘超); Li MM; Wang JD; Xianyu YL; Hu GQ(胡国庆); Jiang XY; Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China.
Source PublicationBIOMICROFLUIDICS
2013-02-04
Volume7Issue:1Pages:011802/1-011802/11
ISSN1932-1058
AbstractIn this work, we propose a rapid and continuous rare tumor cell separation based on hydrodynamic effects in a label-free manner. The competition between the inertial lift force and Dean drag force inside a double spiral microchannel results in the size-based cell separation of large tumor cells and small blood cells. The mechanism of hydrodynamic separation in curved microchannel was investigated by a numerical model. Experiments with binary mixture of 5- and 15-mu m-diameter polystyrene particles using the double spiral channel showed a separation purity of more than 95% at the flow rate above 30 ml/h. High throughput (2.5 x 10(8) cells/min) and efficient cell separation (more than 90%) of spiked HeLa cells and 20 x diluted blood cells was also achieved by the double spiral channel.
KeywordBiomems Cellular Biophysics Hydrodynamics Microchannel Flow Tumours
Subject Area微机电系统中的流体力学问题
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Indexed BySCI ; EI
Language英语
WOS IDWOS:000315597100008
Funding OrganizationMOST [2011CB933201, 2009CB930001, 2011CB707604]; NSFC [51105086, 21025520, 90813032, 50890182]; CAS [KJCX2-YW-M15, KJCX2-YW-H18]
DepartmentLNM微纳米流体力学
Classification一类
Citation statistics
Cited Times:98[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/47122
Collection非线性力学国家重点实验室
Corresponding AuthorHu, GQ (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Sun JS,Liu C,Li MM,et al. Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels[J]. BIOMICROFLUIDICS,2013,7(1):011802/1-011802/11.
APA Sun JS.,刘超.,Li MM.,Wang JD.,Xianyu YL.,...&Hu, GQ .(2013).Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels.BIOMICROFLUIDICS,7(1),011802/1-011802/11.
MLA Sun JS,et al."Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels".BIOMICROFLUIDICS 7.1(2013):011802/1-011802/11.
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