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Title:
Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels
Author: Sun JS; Liu C(刘超); Li MM; Wang JD; Xianyu YL; Hu GQ(胡国庆); Jiang XY
Source: BIOMICROFLUIDICS
Issued Date: 2013-02-04
Volume: 7, Issue:1, Pages:011802/1-011802/11
Abstract: In this work, we propose a rapid and continuous rare tumor cell separation based on hydrodynamic effects in a label-free manner. The competition between the inertial lift force and Dean drag force inside a double spiral microchannel results in the size-based cell separation of large tumor cells and small blood cells. The mechanism of hydrodynamic separation in curved microchannel was investigated by a numerical model. Experiments with binary mixture of 5- and 15-mu m-diameter polystyrene particles using the double spiral channel showed a separation purity of more than 95% at the flow rate above 30 ml/h. High throughput (2.5 x 10(8) cells/min) and efficient cell separation (more than 90%) of spiked HeLa cells and 20 x diluted blood cells was also achieved by the double spiral channel.
Keyword: bioMEMS ; cellular biophysics ; hydrodynamics ; microchannel flow ; tumours
Language: 英语
Indexed Type: SCI ; EI
Corresponding Author: Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China.
Correspondent Email: guoqing.hu@imech.ac.cn; xingyujiang@nanoctr.cn
Related URLs: 查看原文
WOS ID: WOS:000315597100008
ISSN: 1932-1058
Rank: [Sun, Jiashu; Li, Mengmeng; Wang, Jidong; Xianyu, Yunlei; Jiang, Xingyu] Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; [Liu, Chao; Hu, Guoqing] Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China
Subject: 流体力学::微机电系统中的流体力学问题
Department: LNM微纳米流体力学
Classification: 一类
Citation statistics:
Content Type: 期刊论文
URI: http://dspace.imech.ac.cn/handle/311007/47122
Appears in Collections:非线性力学国家重点实验室_期刊论文

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Recommended Citation:
Sun JS,Liu C,Li MM,et al. Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels[J]. BIOMICROFLUIDICS,2013-02-04,7(1):011802/1-011802/11.
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