IMECH-IR  > 国家微重力实验室
基底微拓扑结构对细胞生物学行为的影响
Alternative TitleImpacts of surface micro-topography on cellular biological responses
宫元卫; 孙树津; 吕东媛; 李展; 龙勉
Source Publication医用生物力学
2013-02-15
Volume28Issue:1Pages:115-120
ISSN1004-7220
Abstract与常规的细胞体外培养器皿不同,细胞在体内生长时,其微环境并不是简单的平面形式,每一种组织都有其特定的三维微结构。这类具有微结构的微环境是细胞生长、分化的重要调控因子。近年关于基底微拓扑结构影响细胞生长、分化等行为研究的文献迅速增加,研究发现,具有微拓扑结构的基底可改变细胞的铺展、迁移、取向等行为,引导细胞骨架的重排,调控干细胞分化潜能,对于体外组织构建以及医学植入材料的表面处理具有指导性意义。本文就有关基底微拓扑结构影响细胞生物学研究的最新进展进行了综述。
Other AbstractCulturing cells on planar substrate in vitro is a conventional cell biology method. However, each type of physiological tissues has its specific three-dimensional micro-structure, which provides various micro-environment to regulate such biological processes as cell proliferation and differentiation. To date, a growing body of research on the impacts of substrate micro-topography on cellular responses has been documented in the literature. It is found that micro-topographical substrate can manipulate cell spreading, migrating, orientating, cytoskeleton remodeling, and stem cell differentiation, which are crucial to ex vivo tissue construction and surface modification of medical implanting materials. The recent advance about effects of substrate micro-topography on cellular responses and the underlying mechanisms of mechano-biological coupling is discussed in this review.
Keyword基底微拓扑结构 细胞增殖 干细胞分化 细胞骨架
Subject Area生物力学
URL查看原文
Indexed ByCSCD
Language中文
Funding Organization国家自然科学基金资助项目(31110103918,30870601);国家重点基础研究发展计划(973计划)(2011CB710904);中科院先导专项(XDA01030102)
CSCD IDCSCD:4771252
DepartmentNML分子-细胞生物力学与空间生命科学
Citation statistics
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/47134
Collection国家微重力实验室
Corresponding Author孙树津; 龙勉
Recommended Citation
GB/T 7714
宫元卫,孙树津,吕东媛,等. 基底微拓扑结构对细胞生物学行为的影响[J]. 医用生物力学,2013,28(1):115-120.
APA 宫元卫,孙树津,吕东媛,李展,&龙勉.(2013).基底微拓扑结构对细胞生物学行为的影响.医用生物力学,28(1),115-120.
MLA 宫元卫,et al."基底微拓扑结构对细胞生物学行为的影响".医用生物力学 28.1(2013):115-120.
Files in This Item: Download All
File Name/Size DocType Version Access License
IMCAS-J2013-096.pdf(477KB) 开放获取--View Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[宫元卫]'s Articles
[孙树津]'s Articles
[吕东媛]'s Articles
Baidu academic
Similar articles in Baidu academic
[宫元卫]'s Articles
[孙树津]'s Articles
[吕东媛]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[宫元卫]'s Articles
[孙树津]'s Articles
[吕东媛]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: IMCAS-J2013-096.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.