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Advances in the understanding of nanomaterial-biomembrane interactions and their mathematical and numerical modeling
Qu, Zhi Guo1,2; He, Xiao Cong1,2; Lin, Min2,3; Sha, Bao Yong2,4; Shi, Xing Hua5; Lu, Tian Jian2; Xu, Feng2,3; Xu, F (reprint author), Xi An Jiao Tong Univ, Bioinspired Engn & Biomech Ctr, Xian 710049, Peoples R China.
Source PublicationNANOMEDICINE
2013-06-01
Volume8Issue:6Pages:995-1011
ISSN1743-5889
AbstractThe widespread application of nanomaterials (NMs), which has accompanied advances in nanotechnology, has increased their chances of entering an organism, for example, via the respiratory system, skin absorption or intravenous injection. Although accumulating experimental evidence has indicated the important role of NM-biomembrane interaction in these processes, the underlying mechanisms remain unclear. Computational techniques, as an alternative to experimental efforts, are effective tools to simulate complicated biological behaviors. Computer simulations can investigate NM-biomembrane interactions at the nanoscale, providing fundamental insights into dynamic processes that are challenging to experimental observation. This paper reviews the current understanding of NM-biomembrane interactions, and existing mathematical and numerical modeling methods. We highlight the advantages and limitations of each method, and also discuss the future perspectives in this field. Better understanding of NM-biomembrane interactions can benefit various fields, including nanomedicine and diagnosis.; The widespread application of nanomaterials (NMs), which has accompanied advances in nanotechnology, has increased their chances of entering an organism, for example, via the respiratory system, skin absorption or intravenous injection. Although accumulating experimental evidence has indicated the important role of NM-biomembrane interaction in these processes, the underlying mechanisms remain unclear. Computational techniques, as an alternative to experimental efforts, are effective tools to simulate complicated biological behaviors. Computer simulations can investigate NM-biomembrane interactions at the nanoscale, providing fundamental insights into dynamic processes that are challenging to experimental observation. This paper reviews the current understanding of NM-biomembrane interactions, and existing mathematical and numerical modeling methods. We highlight the advantages and limitations of each method, and also discuss the future perspectives in this field. Better understanding of NM-biomembrane interactions can benefit various fields, including nanomedicine and diagnosis.
KeywordBiomembrane Interaction Mathematical Modeling Nanomaterial Numerical Modeling
Subject Area交叉与边缘领域的力学
DOI10.2217/NNM.13.81
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000319867000019
WOS KeywordRECEPTOR-MEDIATED ENDOCYTOSIS ; MOLECULAR-DYNAMICS SIMULATION ; SUPPORTED LIPID-BILAYERS ; SUPERPARAMAGNETIC IRON-OXIDE ; INDUCED PORE FORMATION ; COARSE-GRAINED MODEL ; GOLD NANOPARTICLES ; CELLULAR UPTAKE ; COMPUTER-SIMULATION ; CARBON NANOTUBES
WOS Research AreaBiotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS SubjectBiotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
Funding OrganizationNational Natural Science Foundation of China(10825210 ; National Natural Science Foundation of China [10825210, 31050110125, 11272327]; National 111 Project of China [B06024]; China Young 1000-Talent Program; Shaanxi 100-Talent Program; Program for New Century Excellent Talents in University [NCET-12-0437]; International S&T Cooperation Program of China [2013DFG02930] ; National 111 Project of China(B06024) ; China Young 1000-Talent Program ; Shaanxi 100-Talent Program ; Program for New Century Excellent Talents in University(NCET-12-0437) ; International S&T Cooperation Program of China(2013DFG02930) ; 31050110125 ; 11272327)
DepartmentLNM微结构计算力学(筹)
Classification二类/Q1
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/47348
Collection非线性力学国家重点实验室
Corresponding AuthorXu, F (reprint author), Xi An Jiao Tong Univ, Bioinspired Engn & Biomech Ctr, Xian 710049, Peoples R China.
Affiliation1.Xi An Jiao Tong Univ, Sch Energy & Power Engn, Minist Educ, Key Lab Thermo Fluid Sci & Engn, Xian 710049, Peoples R China
2.Xi An Jiao Tong Univ, Bioinspired Engn & Biomech Ctr, Xian 710049, Peoples R China
3.Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn, Xian 710049, Peoples R China
4.Xian Med Univ, Lab Cell Biol & Translat Med, Xian 710021, Peoples R China
5.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Qu, Zhi Guo,He, Xiao Cong,Lin, Min,et al. Advances in the understanding of nanomaterial-biomembrane interactions and their mathematical and numerical modeling[J]. NANOMEDICINE,2013,8(6):995-1011
APA Qu, Zhi Guo.,He, Xiao Cong.,Lin, Min.,Sha, Bao Yong.,Shi, Xing Hua.,...&Xu, F .(2013).Advances in the understanding of nanomaterial-biomembrane interactions and their mathematical and numerical modeling.NANOMEDICINE,8(6),995-1011.
MLA Qu, Zhi Guo,et al."Advances in the understanding of nanomaterial-biomembrane interactions and their mathematical and numerical modeling".NANOMEDICINE 8.6(2013):995-1011.
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