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A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles
Sun JS; Xianyu YL; Li MM; Liu WW; Zhang L; Liu DB; Liu C(刘超); Hu GQ(胡国庆); Jiang XY; Jiang, XY (reprint author), Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
Source PublicationNANOSCALE
2013-06-21
Volume5Issue:12Pages:5262-5265
ISSN2040-3364
AbstractThis report demonstrates a microfluidic origami chip to synthesize monodisperse, doxorubicin-loaded poly(lactic-co-glycolic acid) nanoparticles with diameters of ~100 nm, a size optimized for cellular uptake and anticancer efficacy, but difficult to achieve with existing approaches. This three-dimensional design in a microchannel may allow for the fabrication of polymeric nanoparticles in this size regime with ease.
KeywordMicrofluidics - Nanoparticles - Synthesis (Chemical) -- Cellular Uptake - Functionalized - Mono-disperse - Poly Lactic-co-glycolic Acid - Polymeric Nanoparticles - Three-dimensional Designs
Subject Area微机电系统中的流体力学问题
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Indexed BySCI ; EI
Language英语
WOS IDWOS:000319756200011
Funding OrganizationMOST [2009CB930001, 2011CB933201, 2012AA030308, 2011CB707604]; NSFC [51105086, 21025520, 51073045, 11272321]; CAS [KJCX2-YW-M15, KJCX2-YW-H18]; [SKLEAC201207]
DepartmentLNM微纳米流体力学
Classification一类
Citation statistics
Cited Times:51[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/47352
Collection非线性力学国家重点实验室
Corresponding AuthorJiang, XY (reprint author), Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Sun JS,Xianyu YL,Li MM,et al. A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles[J]. NANOSCALE,2013,5(12):5262-5265.
APA Sun JS.,Xianyu YL.,Li MM.,Liu WW.,Zhang L.,...&Jiang, XY .(2013).A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles.NANOSCALE,5(12),5262-5265.
MLA Sun JS,et al."A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles".NANOSCALE 5.12(2013):5262-5265.
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