A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles

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	A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles
	Sun JS; Xianyu YL; Li MM; Liu WW; Zhang L; Liu DB; Liu C(刘超); Hu GQ(胡国庆); Jiang XY; Jiang, XY (reprint author), Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
发表期刊	NANOSCALE
	2013-06-21
卷号	5 期号:12 页码:5262-5265
ISSN	2040-3364
摘要	This report demonstrates a microfluidic origami chip to synthesize monodisperse, doxorubicin-loaded poly(lactic-co-glycolic acid) nanoparticles with diameters of ～100 nm, a size optimized for cellular uptake and anticancer efficacy, but difficult to achieve with existing approaches. This three-dimensional design in a microchannel may allow for the fabrication of polymeric nanoparticles in this size regime with ease.
关键词	Microfluidics - Nanoparticles - Synthesis (Chemical) -- Cellular Uptake - Functionalized - Mono-disperse - Poly Lactic-co-glycolic Acid - Polymeric Nanoparticles - Three-dimensional Designs
学科领域	微机电系统中的流体力学问题
URL	查看原文
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000319756200011
项目资助者	MOST [2009CB930001, 2011CB933201, 2012AA030308, 2011CB707604]; NSFC [51105086, 21025520, 51073045, 11272321]; CAS [KJCX2-YW-M15, KJCX2-YW-H18]; [SKLEAC201207]
课题组名称	LNM微纳米流体力学
论文分区	一类
引用统计	被引频次：78[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/47352
专题	非线性力学国家重点实验室
通讯作者	Jiang, XY (reprint author), Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
推荐引用方式 GB/T 7714	Sun JS,Xianyu YL,Li MM,et al. A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles[J]. NANOSCALE,2013,5,12,:5262-5265.
APA	Sun JS.,Xianyu YL.,Li MM.,Liu WW.,Zhang L.,...&Jiang, XY .(2013).A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles.NANOSCALE,5(12),5262-5265.
MLA	Sun JS,et al."A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles".NANOSCALE 5.12(2013):5262-5265.

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