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Cellular entry of graphene nanosheets: The role of thickness, oxidation and surface adsorption
Wang JL(王九令); Wei YJ(魏宇杰); Shi XH(施兴华); Gao HJ; Shi, XH (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.
Source PublicationRSC ADVANCES
2013-09-28
Volume3Issue:36Pages:15776-15782
ISSN2046-2069
AbstractCoarse grained molecular dynamics simulations are conducted to study the interaction of graphene nanosheets with a lipid bilayer, focusing on the effects of graphene thicknesses (single/multi-layered graphene), oxidation and surface absorption by lipid molecules. The results show that a hydrophobic corner of graphene can pierce into the bilayer, while different oxidations of the nanosheets affect their final equilibrium configurations in the bilayer: lying across or within the hydrophobic core of the bilayer. The underlying mechanism is clarified by calculating the energy barrier for graphene piercing into the bilayer. Our studies provide fundamental guidance towards understanding how graphene enters cells, which is important for biomedical diagnostics and therapies, and for managing health impacts following occupational or environmental exposure.
KeywordCarbon Nanotubes Graphene Nanosheets Lipid-bilayers Coarse-grained Model Molecular-dynamics Hydrophobicity Surface Absorption Oxidation Bio Medical Diagnosticscarbon Nanotubes Graphene Nanosheets Lipid-bilayers Coarse-grained Model Molecular-dynamics Hydrophobicity Surface Absorption Oxidation Bio Medical Diagnostics
Subject Area固体力学
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Indexed BySCI ; EI
Language英语
WOS IDWOS:000323271700037
Funding OrganizationNational Natural Science Foundation of China (NSFC) [11272327]; National Science Foundation (NSF) [CMMI-1028530]; Supercomputing Center of Chinese Academy of Sciences (SCCAS)
DepartmentLNM微结构计算力学(筹)
Classification二类/Q2
Citation statistics
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/47462
Collection非线性力学国家重点实验室
Corresponding AuthorShi, XH (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Wang JL,Wei YJ,Shi XH,et al. Cellular entry of graphene nanosheets: The role of thickness, oxidation and surface adsorption[J]. RSC ADVANCES,2013,3(36):15776-15782.
APA Wang JL,Wei YJ,Shi XH,Gao HJ,&Shi, XH .(2013).Cellular entry of graphene nanosheets: The role of thickness, oxidation and surface adsorption.RSC ADVANCES,3(36),15776-15782.
MLA Wang JL,et al."Cellular entry of graphene nanosheets: The role of thickness, oxidation and surface adsorption".RSC ADVANCES 3.36(2013):15776-15782.
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