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Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona
Hu GQ(胡国庆); Jiao B(焦豹); Shi XH(施兴华); Valle RP; Fan QH; Zuo YY; Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China
Source PublicationACS Nano
2013-12
Volume7Issue:12Pages:10525-10533
ISSN1936-0851
AbstractInteraction with the pulmonary surfactant film, being the first line of host defense, represents the initial bio-nano interaction in the lungs. Such interaction determines the fate of the inhaled nanoparticles and their potential therapeutic or toxicological effect. Despite considerable progress in optimizing physicochemical properties of nanoparticles for improved delivery and targeting, the mechanisms by which inhaled nanoparticles interact with the pulmonary surfactant film are still largely unknown. Here, using combined in vitro and in silico methods, we show how hydrophobicity and surface charge of nanoparticles differentially regulate the translocation and interaction with the pulmonary surfactant film. While hydrophilic nanoparticles generally translocate quickly across the pulmonary surfactant film, a significant portion of hydrophobic nanoparticles are trapped by the surfactant film and encapsulated in lipid protrusions upon film compression. Our results support a novel model of pulmonary surfactant lipoprotein corona associated with inhaled nanoparticles of different physicochemical properties. Our data suggest that the study of pulmonary nanotoxicology and nanoparticle-based pulmonary drug delivery should consider this lipoprotein corona.
KeywordNanoparticle Protein Corona Pulmonary Surfactant Molecular Dynamics
Subject Area交叉与边缘领域的力学
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Indexed BySCI ; EI
Language英语
WOS IDWOS:000329137100011
Funding OrganizationMOST [2011CB707604]; NSFC [11272321, 11272327]; NSF [CBET-1236596]
DepartmentLNM微纳米流体力学
Classification一类
Citation statistics
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/47742
Collection非线性力学国家重点实验室
Corresponding AuthorHu, GQ (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Hu GQ,Jiao B,Shi XH,et al. Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona[J]. ACS Nano,2013,7(12):10525-10533
APA Hu GQ.,Jiao B.,Shi XH.,Valle RP.,Fan QH.,...&Hu, GQ .(2013).Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona.ACS Nano,7(12),10525-10533.
MLA Hu GQ,et al."Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona".ACS Nano 7.12(2013):10525-10533.
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