Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona

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	Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona
	Hu GQ(胡国庆); Jiao B(焦豹); Shi XH(施兴华); Valle RP; Fan QH; Zuo YY; Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China
发表期刊	ACS Nano
	2013-12
卷号	7 期号:12 页码:10525-10533
ISSN	1936-0851
摘要	Interaction with the pulmonary surfactant film, being the first line of host defense, represents the initial bio-nano interaction in the lungs. Such interaction determines the fate of the inhaled nanoparticles and their potential therapeutic or toxicological effect. Despite considerable progress in optimizing physicochemical properties of nanoparticles for improved delivery and targeting, the mechanisms by which inhaled nanoparticles interact with the pulmonary surfactant film are still largely unknown. Here, using combined in vitro and in silico methods, we show how hydrophobicity and surface charge of nanoparticles differentially regulate the translocation and interaction with the pulmonary surfactant film. While hydrophilic nanoparticles generally translocate quickly across the pulmonary surfactant film, a significant portion of hydrophobic nanoparticles are trapped by the surfactant film and encapsulated in lipid protrusions upon film compression. Our results support a novel model of pulmonary surfactant lipoprotein corona associated with inhaled nanoparticles of different physicochemical properties. Our data suggest that the study of pulmonary nanotoxicology and nanoparticle-based pulmonary drug delivery should consider this lipoprotein corona.
关键词	Nanoparticle Protein Corona Pulmonary Surfactant Molecular Dynamics
学科领域	交叉与边缘领域的力学
URL	查看原文
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000329137100011
项目资助者	MOST [2011CB707604]; NSFC [11272321, 11272327]; NSF [CBET-1236596]
课题组名称	LNM微纳米流体力学
论文分区	一类
引用统计	被引频次：174[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/47742
专题	非线性力学国家重点实验室
通讯作者	Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Hu GQ,Jiao B,Shi XH,et al. Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona[J]. ACS Nano,2013,7,12,:10525-10533.
APA	Hu GQ.,Jiao B.,Shi XH.,Valle RP.,Fan QH.,...&Hu, GQ .(2013).Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona.ACS Nano,7(12),10525-10533.
MLA	Hu GQ,et al."Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona".ACS Nano 7.12(2013):10525-10533.

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