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Molecular analysis of interactions between dendrimers and asymmetric membranes at different transport stages
He XC; Qu ZG; Xu F; Lin M; Wang JL(王九令); Shi XH(施兴华); Lu TJ; Qu, ZG (reprint author), Xi An Jiao Tong Univ, Minist Educ, Sch Energy & Power Engn, Key Lab Thermofluid Sci & Engn, Xian 710049, Peoples R China.
Source PublicationSOFT MATTER
2014-01-07
Volume10Issue:1Pages:139-148
ISSN1744-683X
AbstractStudying dendrimer-biomembrane interactions is important for understanding drug and gene delivery. In this study, coarse-grained molecular dynamics simulations were performed to investigate the behaviors of polyamidoamine (PAMAM) dendrimers (G4 and G5) as they interacted with asymmetric membranes from different sides of the bilayer, thus mimicking different dendrimer transport stages. The G4 dendrimer could insert into the membrane during an equilibrated state, and the G5 dendrimer could induce pore formation in the membrane when the dendrimers interacted with the outer side (outer interactions) of an asymmetric membrane [with 10% dipalmitoyl phosphatidylserine (DPPS) in the inner leaflet of the membrane]. During the interaction with the inner side of the asymmetric membrane (inner interactions), the G4 and G5 dendrimers only adsorbed onto the membrane. As the membrane asymmetry increased (e.g., increased DPPS percentage in the inner leaflet of the membrane), the G4 and G5 dendrimers penetrated deeper into the membrane during the outer interactions and the G4 and G5 dendrimers were adsorbed more tightly onto the membrane for the inner interactions. When the DPPS content reached 50%, the G4 dendrimer could completely penetrate through the membrane from the outer side to the inner side. Our study provides molecular understanding and reference information about different dendrimer transport stages during drug and gene delivery.
Subject Area交叉与边缘领域的力学
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Indexed BySCI ; EI
Language英语
WOS IDWOS:000327849000016
Funding OrganizationNational Natural Science Foundation of China [51322604, 11272327, 11372243]; National 111 Project of China [B06024]; Major International Joint Research Program of China [11120101002]; Key Project of Chinese Ministry of Education [313045]; South Wisdom Valley Innovative Research Team Program; International Science & Technology Cooperation Program of China [2013DFG02930]; China Young 1000-Talent Program; Program for New Century Excellent Talents in University [NCET-12-0437]
DepartmentLNM微结构计算力学(筹)
Classification一类
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/48082
Collection非线性力学国家重点实验室
Corresponding AuthorQu, ZG (reprint author), Xi An Jiao Tong Univ, Minist Educ, Sch Energy & Power Engn, Key Lab Thermofluid Sci & Engn, Xian 710049, Peoples R China.
Recommended Citation
GB/T 7714
He XC,Qu ZG,Xu F,et al. Molecular analysis of interactions between dendrimers and asymmetric membranes at different transport stages[J]. SOFT MATTER,2014,10(1):139-148.
APA He XC.,Qu ZG.,Xu F.,Lin M.,Wang JL.,...&Qu, ZG .(2014).Molecular analysis of interactions between dendrimers and asymmetric membranes at different transport stages.SOFT MATTER,10(1),139-148.
MLA He XC,et al."Molecular analysis of interactions between dendrimers and asymmetric membranes at different transport stages".SOFT MATTER 10.1(2014):139-148.
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