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Hydrodynamic cell enrichment in double spiral microfluidic channels
Sun JS; Li MM; Liu C(刘超); Hu GQ(胡国庆); Jiang XY; Sun Jiashu
Source PublicationChemical Sensors 10 -and- MEMS/NEMS 10
Conference NameSymposia on Chemical Sensors 10 - Chemical and Biological Sensors and Analytical Systems and Microfabricated and Nanofabricated Systems for MEMS/NEMS 10 - 222nd ECS Meeting/PRiME 2012
Conference DateOCT 07-12, 2012
Conference PlaceHonolulu, HI, United states
AbstractRapid cell separation and enrichment has attracted significant attention because of its important applications in cell biology studies and biomedical diagnostics. we have developed a compact microfluidic platform, composed of 6-loop double spiral microchannels, to separate cancer cells from blood cells. The curved geometry induces a Dean drag force acting on cells to compete with the inertial lift, resulting in different equilibrium positions for different sized cells. The separation chip is characterized with the mixture of 4T1 cells and the murine blood cells at different flow rates, with decent separation and enrichment efficiency.
WOS IDWOS:000338266800056
Funding OrganizationMOST 2011CB933201 2009CB930001 2011CB707604 NSFC 51105086 21025520 90813032 CAS KJCX2-YW-M15 KJCX2YW-H18
Indexed ByCPCI-S ; EI
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type会议论文
Corresponding AuthorSun Jiashu
Recommended Citation
GB/T 7714
Sun JS,Li MM,Liu C,et al. Hydrodynamic cell enrichment in double spiral microfluidic channels[C]Chemical Sensors 10 -and- MEMS/NEMS 10,2012:441-445.
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