IMECH-IR  > 国家微重力实验室
整合素Mac-1/LFA-1力谱动力学差异
王曼柳; 李宁; 章燕; 吕守芹; 龙勉
Source Publication第十届全国生物力学学术会议暨第十二届全国生物流变学学术会议论文摘要汇编
2012
Pages283-284
Conference Name第十届全国生物力学学术会议暨第十二届全国生物流变学学术会议
Conference Date2012-10-11
Conference Place中国四川成都
Abstract炎症反应过程中,白细胞穿出血管内皮细胞向炎症部位募集的过程分为捕获,滚动,慢速滚动,稳定粘附,爬行,跨内皮迁移等多个步骤。其中慢速滚动、稳定粘附和爬行则是由β_2整合素与其配体ICAM-1(Intercellular Adhesive Molecule-1)相互作用介导的。β_2整合素的两个亚型,LFA-1(Lymphocyte Function-associated Antigen-1,α_Lβ_2,CD11 a/CD18)和Mac-1(Macrophage-1 antigen,α_Mβ_2,CD11 b/CDl8)结构非常相似,均由α和β两个亚基组成的异源二聚体,具有相同的β亚基,通...
KeywordMac-/lfa- 整合素 动力学环境 相互作用 力谱 断裂力 加载率 配体 亚基 Antigen 血管内皮细胞 慢速 炎症反应 功能关系 白细胞 粘附 Associated 亲和性 生理条件 介导的
DepartmentNML分子-细胞生物力学与空间生命科学
Language中文
Document Type会议论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/48373
Collection国家微重力实验室
Recommended Citation
GB/T 7714
王曼柳,李宁,章燕,等. 整合素Mac-1/LFA-1力谱动力学差异[C]第十届全国生物力学学术会议暨第十二届全国生物流变学学术会议论文摘要汇编,2012:283-284.
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