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A Universal Law for Cell Uptake of One-Dimensional Nanomaterials
Yi, X; Shi XH(施兴华); Gao HJ(高华健); Gao, HJ (reprint author), Brown Univ, Sch Engn, Providence, RI 02912 USA.
Source PublicationNano Letters
2014-02
Volume14Issue:2Pages:1049-1055
ISSN1530-6984
AbstractUnderstanding cell interaction with one-dimensional nanomaterials, including nanotubes, nanowires, nanofibers, filamentous bacteria, and certain nanoparticle chains, has fundamental importance to many applications such as biomedical diagnostics, therapeutics, and nanotoxicity. Here we show that cell uptake of one-dimensional nanomaterials via receptor-mediated endocytosis is dominated by a single dimensionless parameter that scales with the membrane tension and radius of the nanomaterial and inversely with the membrane bending stiffness. It is shown that as cell membrane internalizes one-dimensional nanomaterials the uptake follows a near-perpendicular entry mode at small membrane tension but it switches to a near-parallel interaction mode at large membrane tension.
KeywordBulk Shear Strength Of Adhesive Overall Strength Toughness Adhesive Thickness
Subject AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
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Indexed BySCI ; EI
Language英语
WOS IDWOS:000331343900101
Funding OrganizationX.Y. and H.C. acknowledge support by the National Science Foundation under INSPIRE: "Computational Design for the Safe Development of High-Aspect-Ratio Nanomaterials", GBET-1344097, and one of its predecessor grants, CMMI-1028530; X.S. acknowledges support by the National Natural Science Foundation of China (Grant 11272327 and 11023001).
DepartmentLNM微结构计算力学(筹)
Classification一类
Citation statistics
Cited Times:66[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/48768
Collection非线性力学国家重点实验室
Corresponding AuthorGao, HJ (reprint author), Brown Univ, Sch Engn, Providence, RI 02912 USA.
Recommended Citation
GB/T 7714
Yi, X,Shi XH,Gao HJ,et al. A Universal Law for Cell Uptake of One-Dimensional Nanomaterials[J]. Nano Letters,2014,14(2):1049-1055
APA Yi, X,Shi XH,Gao HJ,&Gao, HJ .(2014).A Universal Law for Cell Uptake of One-Dimensional Nanomaterials.Nano Letters,14(2),1049-1055.
MLA Yi, X,et al."A Universal Law for Cell Uptake of One-Dimensional Nanomaterials".Nano Letters 14.2(2014):1049-1055.
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