A Universal Law for Cell Uptake of One-Dimensional Nanomaterials

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	A Universal Law for Cell Uptake of One-Dimensional Nanomaterials
	Yi, X; Shi XH(施兴华); Gao HJ(高华健); Gao, HJ (reprint author), Brown Univ, Sch Engn, Providence, RI 02912 USA.
发表期刊	Nano Letters
	2014-02
卷号	14 期号:2 页码:1049-1055
ISSN	1530-6984
摘要	Understanding cell interaction with one-dimensional nanomaterials, including nanotubes, nanowires, nanofibers, filamentous bacteria, and certain nanoparticle chains, has fundamental importance to many applications such as biomedical diagnostics, therapeutics, and nanotoxicity. Here we show that cell uptake of one-dimensional nanomaterials via receptor-mediated endocytosis is dominated by a single dimensionless parameter that scales with the membrane tension and radius of the nanomaterial and inversely with the membrane bending stiffness. It is shown that as cell membrane internalizes one-dimensional nanomaterials the uptake follows a near-perpendicular entry mode at small membrane tension but it switches to a near-parallel interaction mode at large membrane tension.
关键词	Bulk Shear Strength Of Adhesive Overall Strength Toughness Adhesive Thickness
学科领域	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
URL	查看原文
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000331343900101
项目资助者	X.Y. and H.C. acknowledge support by the National Science Foundation under INSPIRE: "Computational Design for the Safe Development of High-Aspect-Ratio Nanomaterials", GBET-1344097, and one of its predecessor grants, CMMI-1028530; X.S. acknowledges support by the National Natural Science Foundation of China (Grant 11272327 and 11023001).
课题组名称	LNM微结构计算力学（筹）
论文分区	一类
引用统计	被引频次：101[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/48768
专题	非线性力学国家重点实验室
通讯作者	Gao, HJ (reprint author), Brown Univ, Sch Engn, Providence, RI 02912 USA.
推荐引用方式 GB/T 7714	Yi, X,Shi XH,Gao HJ,et al. A Universal Law for Cell Uptake of One-Dimensional Nanomaterials[J]. Nano Letters,2014,14,2,:1049-1055.
APA	Yi, X,Shi XH,Gao HJ,&Gao, HJ .(2014).A Universal Law for Cell Uptake of One-Dimensional Nanomaterials.Nano Letters,14(2),1049-1055.
MLA	Yi, X,et al."A Universal Law for Cell Uptake of One-Dimensional Nanomaterials".Nano Letters 14.2(2014):1049-1055.

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