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Computational Modeling of Stem Cell Migration: A Mini Review
Liu XF(刘晓锋); Vargas DA; Lv DY(吕东媛); Zhang Y(章燕); Zaman, MH; Long M(龙勉); Zaman, MH (reprint author), Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA.
AbstractStem cell migration is crucial in many biological processes such as embryogenesis, histogenesis, and stem cell biology. It is also an important process in physiology, and in medicine, it can contribute to develop effective stem cell therapies. While there is a large body of experimental evidence that attempts to understand the biological and physiological mechanisms governing stem cell activity in the organism, computational modeling studies are scarce. Because stem cell migration is affected by biological diversity and the complexity of the cells' microenvironment, experiments are hard to conduct and corresponding measurements are sophisticated. Computational modeling is a good complementary method to help us understand this process. Here, a mini-review is presented discussing the existing efforts and the unsolved key issues in stem cell migration. In addition, existing computational models studying the migration of differentiated cells are briefly discussed in the context of how they can be applied to increase our understanding of the dynamics involved in stem cell migration: Particular emphasis is placed on how biomechanical aspects of migration are explored in these models.
KeywordComputational Modeling Stem Cell Migration Dynamics
Subject AreaCell Biology ; Biophysics
Indexed BySCI
WOS IDWOS:000336333800004
Funding OrganizationThis work was supported by National Natural Science Foundation of China Grant 31110103918, National Key Basic Research Foundation of China grant 2011CB710904, Strategic Priority Research Program grants XDA01030102 and XDA04020219 and Knowledge Innovation Program Grant 2005-1-16 from Chinese Academy of Sciences (M. L.). MHZ acknowledges the generous support of NIH grant (5U01CA177799).
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorZaman, MH (reprint author), Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA.
Recommended Citation
GB/T 7714
Liu XF,Vargas DA,Lv DY,et al. Computational Modeling of Stem Cell Migration: A Mini Review[J]. CELLULAR AND MOLECULAR BIOENGINEERING,2014,7(2):196-204.
APA Liu XF.,Vargas DA.,Lv DY.,Zhang Y.,Zaman, MH.,...&Zaman, MH .(2014).Computational Modeling of Stem Cell Migration: A Mini Review.CELLULAR AND MOLECULAR BIOENGINEERING,7(2),196-204.
MLA Liu XF,et al."Computational Modeling of Stem Cell Migration: A Mini Review".CELLULAR AND MOLECULAR BIOENGINEERING 7.2(2014):196-204.
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