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Cooperative entry of nanoparticles into the cell
Wang JL(王九令); Yao HM(姚海民); Shi XH(施兴华)
Source PublicationJournal of The Mechanics and Physics of Solids
AbstractInteraction of nanoparticles (NPs) with cell membrane is a crucial issue in studying drug delivery, photodynamic therapy system and cytotoxicity. Single NP with relatively small size cannot be fully wrapped by the cell membrane, which prohibits its uptake. One feasible way is cooperative entry, i.e., recruiting and assembling multiple small NPs to form a larger NP cluster to enter into a cell. In this work, we present theoretical analysis about the cooperative entry of multiple NPs. Through free energy calculation we investigate how the NPs׳ size, shape, interval and NP/cell interfacial binding energy influence the feasibility of entry. Interestingly we find that the cooperative entry of oblate ellipsoidal NPs can get larger energy compensation than individual ones as well as spherical ones. We also propose that soft NPs have preference in cooperative entry of the cell. Our work can be used to actively design and transfer NPs in applications such as drug delivery as well as to understand the shape effect on toxic mechanism of ellipsoidal NPs.
KeywordCellular Uptake Cooperative Entry Nanoparticles Spherical Buds
Subject AreaSolid Mechanics
Indexed BySCI ; EI
WOS IDWOS:000347023600011
Funding OrganizationNSFC Grants 11272327,11422215,11023001
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorShi XH(施兴华)
Recommended Citation
GB/T 7714
Wang JL,Yao HM,Shi XH. Cooperative entry of nanoparticles into the cell[J]. Journal of The Mechanics and Physics of Solids,2014,73:151-165.
APA 王九令,姚海民,&施兴华.(2014).Cooperative entry of nanoparticles into the cell.Journal of The Mechanics and Physics of Solids,73,151-165.
MLA 王九令,et al."Cooperative entry of nanoparticles into the cell".Journal of The Mechanics and Physics of Solids 73(2014):151-165.
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