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Joint detection of tumor markers with imaging ellipsometry biosensor
Niu Y(牛宇); Kang TF(康腾飞); Jin G(靳刚); Jin, G (reprint author), 15 Bei Si Huan West Rd, Beijing 100190, Peoples R China.
Source PublicationThin Solid Films
2014-11-28
Volume571Pages:453-462
ISSN0040-6090
AbstractTumor marker detection contributes to the early diagnosis of cancers. However, due to the lack of detection specificity, its results cannot act as a direct evidence to confirm cancer occurrence in clinic. Joint detection of tumor markers may improve the detection specificity. As a trial for clinical diagnosis of hepatocellular carcinoma, alpha-fetoprotein, alpha-L-fucosidase and ferritin have been combined and detected with a label-free, phase sensitive and high throughput imaging ellipsometry biosensor (IEB). Eighty-two sera have been quantitatively detected with IEB and the results are in agreement with the clinical standard approaches. Evaluated by receiver operating characteristic analysis, the specificity of joint detection improves remarkably with IEB for hepatocellular carcinoma. It can be foreseen that the joint detection of tumor markers with IEB has a potential for clinical cancer diagnosis. (C) 2014 Elsevier B.V. All rights reserved.
KeywordJoint Detection Tumor Markers Biosensor Imaging Ellipsometry
Subject AreaMaterials Science ; Physics
DOI10.1016/j.tsf.2014.01.043
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000346055200021
WOS KeywordCANCER ; VISUALIZATION
WOS Research AreaMaterials Science ; Physics
WOS SubjectMaterials Science, Multidisciplinary ; Materials Science, Coatings & Films ; Physics, Applied ; Physics, Condensed Matter
DepartmentNML纳米生物光学
Classification二类/Q2
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/49490
Collection国家微重力实验室
Corresponding AuthorJin, G (reprint author), 15 Bei Si Huan West Rd, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Niu Y,Kang TF,Jin G,et al. Joint detection of tumor markers with imaging ellipsometry biosensor[J]. Thin Solid Films,2014,571:453-462.
APA Niu Y,Kang TF,Jin G,&Jin, G .(2014).Joint detection of tumor markers with imaging ellipsometry biosensor.Thin Solid Films,571,453-462.
MLA Niu Y,et al."Joint detection of tumor markers with imaging ellipsometry biosensor".Thin Solid Films 571(2014):453-462.
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