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Title: Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery
Author: Zhang, L; Feng Q; Wang JL(王九令); Sun, JS; Shi XH(施兴华); Jiang XY
Source: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Issued Date: 2015-03-23
Volume: 54, Issue:13, Pages:3952-3956
Abstract: We present a hollow-structured rigid nanovesicle (RNV) fabricated by a multi-stage microfluidic chip in one step, to effectively entrap various hydrophilic reagents inside, without complicated synthesis, extensive use of emulsifiers and stabilizers, and laborious purification procedures. The RNV contains a hollow water core, a rigid poly (lactic-co-glycolic acid) (PLGA) shell, and an outermost lipid layer. The formation mechanism of the RNV is investigated by dissipative particle dynamics (DPD) simulations. The entrapment efficiency of hydrophilic reagents such as calcein, rhodamine B and siRNA inside the hollow water core of RNV is approximate to 90%. In comparison with the combination of free Dox and siRNA, RNV that co-encapsulate siRNA and doxorubicin (Dox) reveals a significantly enhanced anti-tumor effect for a multidrug resistant tumor model.
Keyword: drug delivery ; hydrophilic reagents ; microfluidics ; nanoparticles ; vesicles
Language: 英语
Indexed Type: SCI ; EI
Corresponding Author: Zhang, L (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, 11 ZhongGuanCun BeiYiTiao, Beijing 100190, Peoples R China.
Correspondent Email: sunjs@nanoctr.cn ; xingyujiang@nanoctr.cn
DOI: 10.1002/anie.201500096
Related URLs: 查看原文
DOC Type: ARTICLE
WOS Subject: Chemistry, Multidisciplinary
WOS Subject Extended: Chemistry
WOS Keyword Plus: POLYMER HYBRID NANOPARTICLES ; CANCER IN-VITRO ; SIRNA DELIVERY ; DRUG-DELIVERY ; BREAST-CANCER ; THERAPY ; VIVO ; SHELL ; COMBINATION ; LIPOSOMES
WOS ID: WOS:000351204600016
ISSN: 1433-7851
Funder: MOST [2013AA032204, 2013YQ190467] ; NSFC [21475028, 21025520, 11422215, 11272327] ; CAS/SAFEA International Partnership Program for Creative Research Teams
Rank: [Zhang, Lu; Feng, Qiang; Sun, Jiashu; Jiang, Xingyu] Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China; [Zhang, Lu; Feng, Qiang; Sun, Jiashu; Jiang, Xingyu] Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; [Wang, Jiuling; Shi, Xinghua] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
Subject: Chemistry, Multidisciplinary
Department: LNM微结构计算力学(筹)
Classification: 一类
Citation statistics:
Content Type: 期刊论文
URI: http://dspace.imech.ac.cn/handle/311007/49906
Appears in Collections:非线性力学国家重点实验室_期刊论文

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