Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery

doi:10.1002/anie.201500096

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	Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery
	Zhang, L; Feng Q; Wang JL(王九令); Sun, JS; Shi XH(施兴华); Jiang XY; Zhang, L (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, 11 ZhongGuanCun BeiYiTiao, Beijing 100190, Peoples R China.
发表期刊	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2015-03-23
卷号	54 期号:13 页码:3952-3956
ISSN	1433-7851
摘要	We present a hollow-structured rigid nanovesicle (RNV) fabricated by a multi-stage microfluidic chip in one step, to effectively entrap various hydrophilic reagents inside, without complicated synthesis, extensive use of emulsifiers and stabilizers, and laborious purification procedures. The RNV contains a hollow water core, a rigid poly (lactic-co-glycolic acid) (PLGA) shell, and an outermost lipid layer. The formation mechanism of the RNV is investigated by dissipative particle dynamics (DPD) simulations. The entrapment efficiency of hydrophilic reagents such as calcein, rhodamine B and siRNA inside the hollow water core of RNV is approximate to 90%. In comparison with the combination of free Dox and siRNA, RNV that co-encapsulate siRNA and doxorubicin (Dox) reveals a significantly enhanced anti-tumor effect for a multidrug resistant tumor model.
关键词	Drug Delivery Hydrophilic Reagents Microfluidics Nanoparticles Vesicles
学科领域	Chemistry, Multidisciplinary
DOI	10.1002/anie.201500096
URL	查看原文
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000351204600016
关键词[WOS]	POLYMER HYBRID NANOPARTICLES ; CANCER IN-VITRO ; SIRNA DELIVERY ; DRUG-DELIVERY ; BREAST-CANCER ; THERAPY ; VIVO ; SHELL ; COMBINATION ; LIPOSOMES
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
项目资助者	MOST [2013AA032204, 2013YQ190467] ; NSFC [21475028, 21025520, 11422215, 11272327] ; CAS/SAFEA International Partnership Program for Creative Research Teams
课题组名称	LNM微结构计算力学（筹）
论文分区	一类
引用统计	被引频次：125[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/49906
专题	非线性力学国家重点实验室
通讯作者	Zhang, L (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, 11 ZhongGuanCun BeiYiTiao, Beijing 100190, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, L,Feng Q,Wang JL,et al. Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54,13,:3952-3956.
APA	Zhang, L.,Feng Q.,Wang JL.,Sun, JS.,Shi XH.,...&Zhang, L .(2015).Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(13),3952-3956.
MLA	Zhang, L,et al."Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.13(2015):3952-3956.

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