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Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery
Zhang, L; Feng Q; Wang JL(王九令); Sun, JS; Shi XH(施兴华); Jiang XY; Zhang, L (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, 11 ZhongGuanCun BeiYiTiao, Beijing 100190, Peoples R China.
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2015-03-23
Volume54Issue:13Pages:3952-3956
ISSN1433-7851
AbstractWe present a hollow-structured rigid nanovesicle (RNV) fabricated by a multi-stage microfluidic chip in one step, to effectively entrap various hydrophilic reagents inside, without complicated synthesis, extensive use of emulsifiers and stabilizers, and laborious purification procedures. The RNV contains a hollow water core, a rigid poly (lactic-co-glycolic acid) (PLGA) shell, and an outermost lipid layer. The formation mechanism of the RNV is investigated by dissipative particle dynamics (DPD) simulations. The entrapment efficiency of hydrophilic reagents such as calcein, rhodamine B and siRNA inside the hollow water core of RNV is approximate to 90%. In comparison with the combination of free Dox and siRNA, RNV that co-encapsulate siRNA and doxorubicin (Dox) reveals a significantly enhanced anti-tumor effect for a multidrug resistant tumor model.
KeywordDrug Delivery Hydrophilic Reagents Microfluidics Nanoparticles Vesicles
Subject AreaChemistry, Multidisciplinary
DOI10.1002/anie.201500096
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000351204600016
WOS KeywordPOLYMER HYBRID NANOPARTICLES ; CANCER IN-VITRO ; SIRNA DELIVERY ; DRUG-DELIVERY ; BREAST-CANCER ; THERAPY ; VIVO ; SHELL ; COMBINATION ; LIPOSOMES
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationMOST [2013AA032204, 2013YQ190467] ; NSFC [21475028, 21025520, 11422215, 11272327] ; CAS/SAFEA International Partnership Program for Creative Research Teams
DepartmentLNM微结构计算力学(筹)
Classification一类
Citation statistics
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/49906
Collection非线性力学国家重点实验室
Corresponding AuthorZhang, L (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, 11 ZhongGuanCun BeiYiTiao, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Zhang, L,Feng Q,Wang JL,et al. Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(13):3952-3956.
APA Zhang, L.,Feng Q.,Wang JL.,Sun, JS.,Shi XH.,...&Zhang, L .(2015).Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(13),3952-3956.
MLA Zhang, L,et al."Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.13(2015):3952-3956.
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