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Size-based separation of particles and cells utilizing viscoelastic effects in straight microchannels
Liu C(刘超); Xue CD; Chen XD(陈晓东); Shan L; Tian Y; Hu GQ(胡国庆); Hu GQ(胡国庆), State Key Laboratory of Nonlinear Mechanics, Institute of Mechanics,Chinese Academy of Sciences, Beijing 100190, China
Source PublicationAnalytical Chemistry
2015-05-19
Volume87Issue:12Pages:6041-6048
ISSN0003-2700
AbstractViscoelasticity-induced particle migration has recently received increasing attention due to its ability to obtain high-quality focusing over a wide range of flow rates. However, its application is limited to low throughput regime since the particles can defocus as flow rate increases. Using an engineered carrier medium with constant and low viscosity and strong elasticity, the sample flow rates are improved to be 1 order of magnitude higher than those in existing studies. Utilizing differential focusing of particles of different sizes, here, we present sheathless particle/cell separation in simple straight microchannels that possess excellent parallelizability for further throughput enhancement. The present method can be implemented over a wide range of particle/cell sizes and flow rates. We successfully separate small particles from larger particles, MCF-7 cells from red blood cells (RBCs), and Escherichia coli (E. coli) bacteria from RBCs in different straight microchannels. The proposed method could broaden the applications of viscoelastic microfluidic devices to particle/cell separation due to the enhanced sample throughput and simple channel design.
DOI10.1021/acs.analchem.5b00516
Indexed BySCI ; EI
Language英语
WOS IDWOS:000356755100027
WOS KeywordVISCOSITY ELASTIC FLUIDS ; MICROFLUIDIC CHANNEL ; FLOW FRACTIONATION ; BLOOD ; CHIP ; MIGRATION ; TECHNOLOGY ; FILTRATION ; CYLINDER ; FOCUSER
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
DepartmentLNM微纳米流体力学
Classification一类
Citation statistics
Cited Times:88[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/52049
Collection非线性力学国家重点实验室
Corresponding AuthorHu GQ(胡国庆), State Key Laboratory of Nonlinear Mechanics, Institute of Mechanics,Chinese Academy of Sciences, Beijing 100190, China
Recommended Citation
GB/T 7714
Liu C,Xue CD,Chen XD,et al. Size-based separation of particles and cells utilizing viscoelastic effects in straight microchannels[J]. Analytical Chemistry,2015,87(12):6041-6048.
APA Liu C.,Xue CD.,Chen XD.,Shan L.,Tian Y.,...&Hu GQ.(2015).Size-based separation of particles and cells utilizing viscoelastic effects in straight microchannels.Analytical Chemistry,87(12),6041-6048.
MLA Liu C,et al."Size-based separation of particles and cells utilizing viscoelastic effects in straight microchannels".Analytical Chemistry 87.12(2015):6041-6048.
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