Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters

doi:10.1063/1.4922957

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	Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters
	Feng Q; Zhang L; Liu C; Li XY; Hu GQ(胡国庆); Sun JS; Jiang XY; Feng, Q (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China.
发表期刊	Biomicrofluidics
	2015-09
卷号	9 期号:5 页码:52604
ISSN	1932-1058
摘要	Core-shell hybrid nanoparticles (NPs) for drug delivery have attracted numerous attentions due to their enhanced therapeutic efficacy and good biocompatibility. In this work, we fabricate a two-stage microfluidic chip to implement a high-throughput, one-step, and size-tunable synthesis of mono-disperse lipid-poly (lactic-co-glycolic acid) NPs. The size of hybrid NPs is tunable by varying the flow rates inside the two-stage microfluidic chip. To elucidate the mechanism of size-controllable generation of hybrid NPs, we observe the flow field in the microchannel with confocal microscope and perform the simulation by a numerical model. Both the experimental and numerical results indicate an enhanced mixing effect at high flow rate, thus resulting in the assembly of small and monodisperse hybrid NPs. In vitro experiments show that the large hybrid NPs are more likely to be aggregated in serum and exhibit a lower cellular uptake efficacy than the small ones. This microfluidic chip shows great promise as a robust platform for optimization of nano drug delivery system. (C) 2015 AIP Publishing LLC.
DOI	10.1063/1.4922957
URL	查看原文
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000364407300005
关键词[WOS]	CORE-SHELL NANOPARTICLES ; CELLULAR UPTAKE ; PLGA NANOPARTICLES ; DRUG-DELIVERY ; PARTICLE-SIZE ; LIPOSOMES ; RELEASE ; DEVICES ; CAPSULES ; PLATFORM
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Science & Technology - Other Topics ; Physics
WOS类目	Biochemical Research Methods ; Biophysics ; Nanoscience & Nanotechnology ; Physics, Fluids & Plasmas
项目资助者	This work was supported financially by MOST (2013AA032204 and 2013YQ190467), NSFC (21475028, 11422215, and 11272327), and Chinese Academy of Sciences (XDA09030305 and XDA09030308).
课题组名称	LNM微纳米流体力学
论文分区	一类
引用统计	被引频次：74[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/52051
专题	非线性力学国家重点实验室
通讯作者	Feng, Q (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China.
推荐引用方式 GB/T 7714	Feng Q,Zhang L,Liu C,et al. Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters[J]. Biomicrofluidics,2015,9,5,:52604.
APA	Feng Q.,Zhang L.,Liu C.,Li XY.,胡国庆.,...&Feng, Q .(2015).Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters.Biomicrofluidics,9(5),52604.
MLA	Feng Q,et al."Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters".Biomicrofluidics 9.5(2015):52604.

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