IMECH-IR  > 非线性力学国家重点实验室
Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters
Feng Q; Zhang L; Liu C; Li XY; Hu GQ(胡国庆); Sun JS; Jiang XY; Feng, Q (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China.
Source PublicationBiomicrofluidics
2015-09
Volume9Issue:5Pages:52604
ISSN1932-1058
AbstractCore-shell hybrid nanoparticles (NPs) for drug delivery have attracted numerous attentions due to their enhanced therapeutic efficacy and good biocompatibility. In this work, we fabricate a two-stage microfluidic chip to implement a high-throughput, one-step, and size-tunable synthesis of mono-disperse lipid-poly (lactic-co-glycolic acid) NPs. The size of hybrid NPs is tunable by varying the flow rates inside the two-stage microfluidic chip. To elucidate the mechanism of size-controllable generation of hybrid NPs, we observe the flow field in the microchannel with confocal microscope and perform the simulation by a numerical model. Both the experimental and numerical results indicate an enhanced mixing effect at high flow rate, thus resulting in the assembly of small and monodisperse hybrid NPs. In vitro experiments show that the large hybrid NPs are more likely to be aggregated in serum and exhibit a lower cellular uptake efficacy than the small ones. This microfluidic chip shows great promise as a robust platform for optimization of nano drug delivery system. (C) 2015 AIP Publishing LLC.
DOI10.1063/1.4922957
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000364407300005
WOS KeywordCORE-SHELL NANOPARTICLES ; CELLULAR UPTAKE ; PLGA NANOPARTICLES ; DRUG-DELIVERY ; PARTICLE-SIZE ; LIPOSOMES ; RELEASE ; DEVICES ; CAPSULES ; PLATFORM
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics ; Science & Technology - Other Topics ; Physics
WOS SubjectBiochemical Research Methods ; Biophysics ; Nanoscience & Nanotechnology ; Physics, Fluids & Plasmas
Funding OrganizationThis work was supported financially by MOST (2013AA032204 and 2013YQ190467), NSFC (21475028, 11422215, and 11272327), and Chinese Academy of Sciences (XDA09030305 and XDA09030308).
DepartmentLNM微纳米流体力学
Classification一类
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/52051
Collection非线性力学国家重点实验室
Corresponding AuthorFeng, Q (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Feng Q,Zhang L,Liu C,et al. Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters[J]. Biomicrofluidics,2015,9(5):52604.
APA Feng Q.,Zhang L.,Liu C.,Li XY.,胡国庆.,...&Feng, Q .(2015).Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters.Biomicrofluidics,9(5),52604.
MLA Feng Q,et al."Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters".Biomicrofluidics 9.5(2015):52604.
Files in This Item:
File Name/Size DocType Version Access License
1.4922957.pdf(2516KB)期刊论文出版稿开放获取CC BY-NDView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Feng Q]'s Articles
[Zhang L]'s Articles
[Liu C]'s Articles
Baidu academic
Similar articles in Baidu academic
[Feng Q]'s Articles
[Zhang L]'s Articles
[Liu C]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Feng Q]'s Articles
[Zhang L]'s Articles
[Liu C]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 1.4922957.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.