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Title: Three-dimensional virtual surgery models for percutaneous coronary intervention (PCI) optimization strategies
Author: Wang HJ; Liu JH; Zheng X(郑旭); Rong XH; Zheng XW; Peng HY; Li ZH(李战华); Li MJ; Liu, LY
Source: SCIENTIFIC REPORTS
Issued Date: 2015-06-04
Volume: 5, Pages:10945
Abstract: Percutaneous coronary intervention (PCI), especially coronary stent implantation, has been shown to be an effective treatment for coronary artery disease. However, in-stent restenosis is one of the longstanding unsolvable problems following PCI. Although stents implanted inside narrowed vessels recover normal flux of blood flows, they instantaneously change the wall shear stress (WSS) distribution on the vessel surface. Improper stent implantation positions bring high possibilities of restenosis as it enlarges the low WSS regions and subsequently stimulates more epithelial cell outgrowth on vessel walls. To optimize the stent position for lowering the risk of restenosis, we successfully established a digital three-dimensional (3-D) model based on a real clinical coronary artery and analysed the optimal stenting strategies by computational simulation. Via microfabrication and 3-D printing technology, the digital model was also converted into in vitro microfluidic models with 3-D micro channels. Simultaneously, physicians placed real stents inside them; i.e., they performed "virtual surgeries". The hydrodynamic experimental results showed that the microfluidic models highly inosculated the simulations. Therefore, our study not only demonstrated that the half-cross stenting strategy could maximally reduce restenosis risks but also indicated that 3-D printing combined with clinical image reconstruction is a promising method for future angiocardiopathy research.
Language: 英语
Indexed Type: SCI
Corresponding Author: Silber-Li, ZH (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.
Correspondent Email: lili@imech.ac.cn ; liu@iphy.ac.cn
DOI: 10.1038/srep10945
Related URLs: 查看原文
DOC Type: Article
WOS Subject: Multidisciplinary Sciences
WOS Subject Extended: Science & Technology - Other Topics
WOS ID: WOS:000355724100001
ISSN: 2045-2322
Funder: State Key Development Program for Basic Research of China [2013CB837200] ; National Natural Science Foundation of China [11474345, 11272322, 11202219] ; Beijing Natural Science Foundation [7154221]
Rank: [Wang, Hujun; Li, Mujun] Univ Sci & Technol China, Dept Precis Machinery & Precis Instrumentat, Hefei 230026, Peoples R China; [Wang, Hujun; Rong, Xiaohui; Liu, Liyu] Chinese Acad Sci, Inst Phys, Key Lab Soft Matter Phys, Beijing 100190, Peoples R China; [Liu, Jinghua; Zheng, Xuwei; Peng, Hongyu] Capital Med Univ, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China; [Zheng, Xu; Silber-Li, Zhanghua] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
Department: LNM微纳米流体力学
Classification: 一类
Citation statistics:
Content Type: 期刊论文
URI: http://dspace.imech.ac.cn/handle/311007/54961
Appears in Collections:非线性力学国家重点实验室_期刊论文

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