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Mechanokinetics of receptor-ligand interactions in cell adhesion
Li N(李宁); Lv SQ(吕守芹); Zhang Y(章燕); Long M(龙勉); Long, M (reprint author), Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China.
Source PublicationActa Mechanica Sinica
2015-04
Volume31Issue:2Pages:248-258
ISSN0567-7718
Abstract

Receptor-ligand interactions in blood flow are crucial to initiate such biological processes as inflammatory cascade, platelet thrombosis, as well as tumor metastasis. To mediate cell adhesion, the interacting receptors and ligands must be anchored onto two apposing surfaces of two cells or a cell and a substratum, i.e., two-dimensional (2D) binding, which is different from the binding of a soluble ligand in fluid phase to a receptor, i.e., three-dimensional (3D) binding. While numerous works have been focused on 3D kinetics of receptor-ligand interactions in the immune system, 2D kinetics and its regulations have been less understood, since no theoretical framework or experimental assays were established until 1993. Not only does the molecular structure dominate 2D binding kinetics, but the shear force in blood flow also regulates cell adhesion mediated by interacting receptors and ligands. Here, we provide an overview of current progress in 2D binding and regulations, mainly from our group. Relevant issues of theoretical frameworks, experimental measurements, kinetic rates and binding affinities, and force regulations are discussed. A neutrophil undergoes capture and rolling (or tethering) on the endothelium through selectin-PSGL-1 bonds, followed by slow rolling and firm adhesion through the -integrins LFA-1 and Mac-1 as well as intraluminal crawling and transmigration through the endothelium to the inflamed tissue.

KeywordReceptor-ligand Interactions Selectins Beta(2) Integrins 2d Binding Kinetics
DOI10.1007/s10409-015-0407-8
URL查看原文
Indexed BySCI ; EI ; CSCD
Language英语
WOS IDWOS:000355315900011
WOS Research AreaEngineering ; Mechanics
WOS SubjectEngineering, Mechanical ; Mechanics
Funding OrganizationNatural Science Foundation of China [10042001, 10072071, 10128205, 30225027, 10332060, 30730032, 11072251, 31110103918] ; National Key Basic Research Foundation of China [2006CB910303, 2011CB710904] ; National High Technology Research and Development Program of China [2007AA02Z306, 2011AA020109] ; Chinese Academy of Sciences [KJCX2-L02, KJCX2-SW-L06, 2005-1-16, KJCX2-YW-L08, Y2010030, XDA01030102, XDA04073 801] ; NIH Fogarty International Research Collaboration Award [TW 05774-01]
DepartmentNML分子-细胞生物力学与空间生命科学
Classification二类
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/54973
Collection国家微重力实验室
Corresponding AuthorLong, M (reprint author), Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Li N,Lv SQ,Zhang Y,et al. Mechanokinetics of receptor-ligand interactions in cell adhesion[J]. Acta Mechanica Sinica,2015,31(2):248-258.
APA Li N,Lv SQ,Zhang Y,Long M,&Long, M .(2015).Mechanokinetics of receptor-ligand interactions in cell adhesion.Acta Mechanica Sinica,31(2),248-258.
MLA Li N,et al."Mechanokinetics of receptor-ligand interactions in cell adhesion".Acta Mechanica Sinica 31.2(2015):248-258.
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