IMECH-IR  > 非线性力学国家重点实验室
Nanotechnology for treating osteoporotic vertebral fractures
Gao CX; Wei DL; Yang HL; Chen T; Yang L; Yang, L (reprint author), Robot Microsyst Ctr, Dept Orthopaed Surg, 708 Renmin Rd, Suzhou 215006, Jiangsu, Peoples R China.
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
2015
Volume10Pages:5139-5157
ISSN1178-2013
AbstractOsteoporosis is a serious public health problem affecting hundreds of millions of aged people worldwide, with severe consequences including vertebral fractures that are associated with significant morbidity and mortality. To augment or treat osteoporotic vertebral fractures, a number of surgical approaches including minimally invasive vertebroplasty and kyphoplasty have been developed. However, these approaches face problems and difficulties with efficacy and long-term stability. Recent advances and progress in nanotechnology are opening up new opportunities to improve the surgical procedures for treating osteoporotic vertebral fractures. This article reviews the improvements enabled by new nanomaterials and focuses on new injectable biomaterials like bone cements and surgical instruments for treating vertebral fractures. This article also provides an introduction to osteoporotic vertebral fractures and current clinical treatments, along with the rationale and efficacy of utilizing nanomaterials to modify and improve biomaterials or instruments. In addition, perspectives on future trends with injectable bone cements and surgical instruments enhanced by nanotechnology are provided.
KeywordNanomaterials Osteoporosis Vertebral Fracture Kyphoplasty Bone Cement Pedicle Screw Radiopacifier
Subject AreaScience & Technology - Other Topics ; Pharmacology & Pharmacy
DOI10.2147/IJN.S85037
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000359447500001
WOS Research AreaScience & Technology - Other Topics ; Pharmacology & Pharmacy
WOS SubjectNanoscience & Nanotechnology ; Pharmacology & Pharmacy
Funding OrganizationJiangsu Provincial Special Program of Medical Science [BL2012004] ; Priority Academic Program Development of Jiangsu High Education Institutions ; National Basic Research Program of China (973 Program) [2014CB748600] ; Jiangsu R&D Innovation Program [BY2014059-07] ; National Natural Science Foundation of China [51472279] ; Jiangsu Six Peak of Talents Program [2013-WSW-056] ; Chinese Ministry of Education Star-up Fund for Oversea Scholars ; Open Fund of State Key Laboratory of Nonlinear Mechanics
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Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/55318
Collection非线性力学国家重点实验室
Corresponding AuthorYang, L (reprint author), Robot Microsyst Ctr, Dept Orthopaed Surg, 708 Renmin Rd, Suzhou 215006, Jiangsu, Peoples R China.
Recommended Citation
GB/T 7714
Gao CX,Wei DL,Yang HL,et al. Nanotechnology for treating osteoporotic vertebral fractures[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2015,10:5139-5157
APA Gao CX,Wei DL,Yang HL,Chen T,Yang L,&Yang, L .(2015).Nanotechnology for treating osteoporotic vertebral fractures.INTERNATIONAL JOURNAL OF NANOMEDICINE,10,5139-5157.
MLA Gao CX,et al."Nanotechnology for treating osteoporotic vertebral fractures".INTERNATIONAL JOURNAL OF NANOMEDICINE 10(2015):5139-5157.
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