| Mechano-biological Coupling of Cellular Responses to Microgravity |
| Long M(龙勉) ; Wang YR(王育人); Zheng HQ; Shang P; Duan EK; Lu DY; Long, M (reprint author), Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, 15 North 4th Ring Rd, Beijing 100190, Peoples R China.
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| 发表期刊 | MICROGRAVITY SCIENCE AND TECHNOLOGY
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| 2015-09
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| 卷号 | 27期号:6页码:505-514 |
| ISSN | 0938-0108
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| 摘要 | Cellular response to microgravity is a basic issue in space biological sciences as well as space physiology and medicine. It is crucial to elucidate the mechano-biological coupling mechanisms of various biological organisms, since, from the principle of adaptability, all species evolved on the earth must possess the structure and function that adapts their living environment. As a basic element of an organism, a cell usually undergoes mechanical and chemical remodeling to sense, transmit, transduce, and respond to the alteration of gravitational signals. In the past decades, new computational platforms and experimental methods/techniques/devices are developed to mimic the biological effects of microgravity environment from the viewpoint of biomechanical approaches. Mechanobiology of plant gravisensing in the responses of statolith movements along the gravity vector and the relevant signal transduction and molecular regulatory mechanisms are investigated at gene, transcription, and protein levels. Mechanotransduction of bone or immune cell responses and stem cell development and tissue histogenesis are elucidated under microgravity. In this review, several important issues are briefly discussed. Future issues on gravisensing and mechanotransducing mechanisms are also proposed for ground-based studies as well as space missions. |
| 关键词 | Microgravity
Mechanobiology
Mechanotransduction
Cells
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| DOI | 10.1007/s12217-015-9464-7
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| URL | 查看原文
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| 收录类别 | SCI
; EI
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| 语种 | 英语
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| WOS记录号 | WOS:000366103800012
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| 关键词[WOS] | EMBRYONIC STEM-CELLS
; ARABIDOPSIS-THALIANA
; SIMULATED MICROGRAVITY
; AMYLOPLAST DISPLACEMENT
; MAGNETIC-FIELD
; IN-VITRO
; GRAVITROPISM
; DIFFERENTIATION
; GRAVITY
; STRESS
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| WOS研究方向 | Engineering
; Thermodynamics
; Mechanics
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| WOS类目 | Engineering, Aerospace
; Thermodynamics
; Mechanics
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| 项目资助者 | This work was supported by National Key Basic Research Foundation of China grant 2011CB710900. The authors are grateful to their contributions of project co-PIs from Profs./Drs. Weiming Cai, Bin Chen, Li Chen, Yubo Fan, Dacheng He, Jie Le, Min Liu, Xiangdong Luo, Dachuan Yin, and Yong Zhao. We also thank to Dr. Debin Mao and Mr. Chengzhi Wang for their technical assistances.
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| 课题组名称 | NML分子-细胞生物力学与空间生命科学
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| 论文分区 | 二类/Q2
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| 引用统计 |
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| 文献类型 | 期刊论文
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| 条目标识符 | http://dspace.imech.ac.cn/handle/311007/58368
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| 专题 | 微重力重点实验室
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| 通讯作者 | Long, M (reprint author), Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, 15 North 4th Ring Rd, Beijing 100190, Peoples R China. |
推荐引用方式
GB/T 7714 |
Long M,Wang YR,Zheng HQ,et al. Mechano-biological Coupling of Cellular Responses to Microgravity[J]. MICROGRAVITY SCIENCE AND TECHNOLOGY,2015,27,6,:505-514.
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| APA |
龙勉.,王育人.,Zheng HQ.,Shang P.,Duan EK.,...&Long, M .(2015).Mechano-biological Coupling of Cellular Responses to Microgravity.MICROGRAVITY SCIENCE AND TECHNOLOGY,27(6),505-514.
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| MLA |
龙勉,et al."Mechano-biological Coupling of Cellular Responses to Microgravity".MICROGRAVITY SCIENCE AND TECHNOLOGY 27.6(2015):505-514.
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