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Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction
Zhang L; Feng Q; Wang JL(王九令); Zhang S; Ding BQ; Wei YJ(魏宇杰); Dong MD; Ryu JY; Yoon TY; Shi XH(施兴华); Sun JS; Jiang XY; Jiang, XY (reprint author), Natl Ctr Nanosci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China.
Source PublicationACS NANO
2015-10
Volume9Issue:10Pages:9912-9921
ISSN1936-0851
Abstract

The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and in vivo stability. Yet few efforts have been made to critically examine the shell structure of nanoparticles and its effect on cell particle interaction. Here we develop a microfluidic chip allowing for the synthesis of structurally well-defined lipid-polymer nanoparticles of the same sizes, but covered with either lipid-monolayer-shell (MPs, monolayer nanoparticles) or lipid-bilayer-shell (BPs, bilayer nanoparticles). Atomic force microscope and atomistic simulations reveal that MPs have a lower flexibility than BPs, resulting in a more efficient cellular uptake and thus anticancer effect than BPs do. This flexibility-regulated cell particle interaction may have important implications for designing drug nanocarriers.

KeywordNanostructures Lipids Microfluidics Interfaces Drug Deliver
DOI10.1021/acsnano.5b05792
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000363915300048
WOS KeywordCore-shell Nanoparticles ; Drug-delivery ; Cancer-therapy ; Nanomaterials ; Entry ; Sirna
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationX.J. and J.S. acknowledge financial support from MOST (2013AA032204, and 2013YQ190467), NSFC (21475028, 21535001, and 81361140345), and Chinese Academy of Sciences (XDA09030305, XDA09030308). X.S. acknowledges financial support from NSFC (11422215, 11272327 and 11023001). The authors thank Dr. Gang Ji and Prof. Fei Sun for the assistance on the Cryo-TEM observation of nanoparticles.
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/58388
Collection非线性力学国家重点实验室
Corresponding AuthorJiang, XY (reprint author), Natl Ctr Nanosci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Zhang L,Feng Q,Wang JL,et al. Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction[J]. ACS NANO,2015,9(10):9912-9921.
APA Zhang L.,Feng Q.,Wang JL.,Zhang S.,Ding BQ.,...&Jiang, XY .(2015).Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction.ACS NANO,9(10),9912-9921.
MLA Zhang L,et al."Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction".ACS NANO 9.10(2015):9912-9921.
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