Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction | |
Zhang L; Feng Q; Wang JL(王九令); Zhang S; Ding BQ; Wei YJ(魏宇杰); Dong MD; Ryu JY; Yoon TY; Shi XH(施兴华); Sun JS; Jiang XY; Jiang, XY (reprint author), Natl Ctr Nanosci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China. | |
发表期刊 | ACS NANO |
2015-10 | |
卷号 | 9期号:10页码:9912-9921 |
ISSN | 1936-0851 |
摘要 | The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and in vivo stability. Yet few efforts have been made to critically examine the shell structure of nanoparticles and its effect on cell particle interaction. Here we develop a microfluidic chip allowing for the synthesis of structurally well-defined lipid-polymer nanoparticles of the same sizes, but covered with either lipid-monolayer-shell (MPs, monolayer nanoparticles) or lipid-bilayer-shell (BPs, bilayer nanoparticles). Atomic force microscope and atomistic simulations reveal that MPs have a lower flexibility than BPs, resulting in a more efficient cellular uptake and thus anticancer effect than BPs do. This flexibility-regulated cell particle interaction may have important implications for designing drug nanocarriers. |
关键词 | Nanostructures Lipids Microfluidics Interfaces Drug Deliver |
DOI | 10.1021/acsnano.5b05792 |
URL | 查看原文 |
收录类别 | SCI ; EI |
语种 | 英语 |
WOS记录号 | WOS:000363915300048 |
关键词[WOS] | Core-shell Nanoparticles ; Drug-delivery ; Cancer-therapy ; Nanomaterials ; Entry ; Sirna |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
项目资助者 | X.J. and J.S. acknowledge financial support from MOST (2013AA032204, and 2013YQ190467), NSFC (21475028, 21535001, and 81361140345), and Chinese Academy of Sciences (XDA09030305, XDA09030308). X.S. acknowledges financial support from NSFC (11422215, 11272327 and 11023001). The authors thank Dr. Gang Ji and Prof. Fei Sun for the assistance on the Cryo-TEM observation of nanoparticles. |
论文分区 | 一类 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://dspace.imech.ac.cn/handle/311007/58388 |
专题 | 非线性力学国家重点实验室 |
通讯作者 | Jiang, XY (reprint author), Natl Ctr Nanosci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China. |
推荐引用方式 GB/T 7714 | Zhang L,Feng Q,Wang JL,et al. Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction[J]. ACS NANO,2015,9,10,:9912-9921. |
APA | Zhang L.,Feng Q.,Wang JL.,Zhang S.,Ding BQ.,...&Jiang, XY .(2015).Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction.ACS NANO,9(10),9912-9921. |
MLA | Zhang L,et al."Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction".ACS NANO 9.10(2015):9912-9921. |
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