中国科学院力学研究所机构知识库
Advanced  
IMECH-IR  > 非线性力学国家重点实验室  > 期刊论文
Title:
Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction
Author: Zhang L; Feng Q; Wang JL; Zhang S; Ding BQ; Wei YJ(魏宇杰); Dong MD; Ryu JY; Yoon TY; Shi XH; Sun JS; Jiang XY
Source: ACS NANO
Issued Date: 2015-10
Volume: 9, Issue:10, Pages:9912-9921
Abstract: The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and in vivo stability. Yet few efforts have been made to critically examine the shell structure of nanoparticles and its effect on cell particle interaction. Here we develop a microfluidic chip allowing for the synthesis of structurally well-defined lipid-polymer nanoparticles of the same sizes, but covered with either lipid-monolayer-shell (MPs, monolayer nanoparticles) or lipid-bilayer-shell (BPs, bilayer nanoparticles). Atomic force microscope and atomistic simulations reveal that MPs have a lower flexibility than BPs, resulting in a more efficient cellular uptake and thus anticancer effect than BPs do. This flexibility-regulated cell particle interaction may have important implications for designing drug nanocarriers.
Keyword: nanostructures ; lipids ; microfluidics ; interfaces ; drug deliver
Language: 英语
Indexed Type: SCI ; EI
Corresponding Author: Jiang, XY (reprint author), Natl Ctr Nanosci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China.
Correspondent Email: shixh@imech.ac.cn ; sunjs@nanoctr.cn ; xingyujiang@nanoctr.cn
DOI: 10.1021/acsnano.5b05792
Related URLs: 查看原文
DOC Type: 期刊论文
WOS Subject: Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS Subject Extended: Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS Keyword Plus: CORE-SHELL NANOPARTICLES ; DRUG-DELIVERY ; CANCER-THERAPY ; NANOMATERIALS ; ENTRY ; SIRNA
WOS ID: WOS:000363915300048
ISSN: 1936-0851
Funder: X.J. and J.S. acknowledge financial support from MOST (2013AA032204, and 2013YQ190467), NSFC (21475028, 21535001, and 81361140345), and Chinese Academy of Sciences (XDA09030305, XDA09030308). X.S. acknowledges financial support from NSFC (11422215, 11272327 and 11023001). The authors thank Dr. Gang Ji and Prof. Fei Sun for the assistance on the Cryo-TEM observation of nanoparticles.
Rank: [Zhang, Lu; Feng, Qiang; Ding, Baoquan; Shi, Xinghua; Sun, Jiashu; Jiang, Xingyu] Natl Ctr Nanosci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China; [Zhang, Lu; Feng, Qiang; Ding, Baoquan; Shi, Xinghua; Sun, Jiashu; Jiang, Xingyu] Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; [Wang, Jiuling; Wei, Yujie] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China; [Zhang, Shuai; Dong, Mingdong] Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, DK-8000 Aarhus C, Denmark; [Ryu, Ji-Young; Yoon, Tae-Young] Korea Adv Inst Sci & Technol, Natl Creat Res Initiat Ctr Single Mol Syst Biol, Taejon 305701, South Korea; [Ryu, Ji-Young; Yoon, Tae-Young] Korea Adv Inst Sci & Technol, Dept Phys, Taejon 305701, South Korea
Department: LNM微结构计算力学(筹)
Classification: 一类
Citation statistics:
Content Type: 期刊论文
URI: http://dspace.imech.ac.cn/handle/311007/58388
Appears in Collections:非线性力学国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
J2015-034.pdf(1699KB)期刊论文作者接受稿开放获取View Download

Recommended Citation:
Zhang L,Feng Q,Wang JL,et al. Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction[J]. ACS NANO,2015-10-01,9(10):9912-9921.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang L]'s Articles
[Feng Q]'s Articles
[Wang JL]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang L]‘s Articles
[Feng Q]‘s Articles
[Wang JL]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: J2015-034.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院力学研究所 - Feedback
Powered by CSpace