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Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film
Hu QL; Jiao B; Shi XH(施兴华); Valle RP; Zuo YY; Hu GQ(胡国庆); Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.
Source PublicationNANOSCALE
2015
Volume7Issue:43Pages:18025-18029
ISSN2040-3364
AbstractGraphene oxide (GO) is the most common derivative of graphene and has been used in a large range of biomedical applications. Despite considerable progress in understanding its cytotoxicity, its potential inhalation toxicity is still largely unknown. As the pulmonary surfactant (PS) film is the first line of host defense, interaction with the PS film determines the fate of the inhaled nanomaterials and their potential toxicity. Using a coarse-grained molecular dynamics model, we reported, for the first time, a novel mechanism of toxicity caused by the inhaled GO nanosheets. Upon deposition, the GO nanosheets induce pores in the PS film and thus have adverse effects on the ultrastructure and biophysical properties of the PS film. Notably, the pores induced by GO nanosheets result in increasing the compressibility of the PS film, which is an important indication of surfactant inhibition. In vitro experiments have also been conducted to study the interactions between GO and animal-derived natural PS films, qualitatively confirming the simulation results.
DOI10.1039/c5nr05401j
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Indexed BySCI ; EI
Language英语
WOS IDWOS:000364048900006
WOS KeywordNANOPARTICLES ; TOXICITY ; TRANSLOCATION ; NANOPLATELETS ; NANOMATERIALS ; CYTOTOXICITY ; SIMULATIONS ; INHIBITION ; MONOLAYER ; SYSTEM
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
Funding OrganizationThis work was financially supported by MOST 2011CB707604, NSFC 11272321 (G.H.), NSF Grant No. CBET-1236596 (Y.Y.Z.), and LNM Open Fund. The MD simulations were performed on TianHe-1(A) at the National Supercomputing Center in Tianjin. We thank Walter Klein at ONY Inc. for donation of Infasurf samples.
DepartmentLNM微纳米流体力学
Classification一类
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/58389
Collection非线性力学国家重点实验室
Corresponding AuthorHu, GQ (reprint author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Hu QL,Jiao B,Shi XH,et al. Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film[J]. NANOSCALE,2015,7(43):18025-18029.
APA Hu QL.,Jiao B.,施兴华.,Valle RP.,Zuo YY.,...&Hu, GQ .(2015).Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film.NANOSCALE,7(43),18025-18029.
MLA Hu QL,et al."Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film".NANOSCALE 7.43(2015):18025-18029.
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