| Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film |
| Hu QL; Jiao B ; Shi XH(施兴华); Valle RP; Zuo YY; Hu GQ(胡国庆); Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.
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| 发表期刊 | NANOSCALE
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| 2015
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| 卷号 | 7期号:43页码:18025-18029 |
| ISSN | 2040-3364
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| 摘要 | Graphene oxide (GO) is the most common derivative of graphene and has been used in a large range of biomedical applications. Despite considerable progress in understanding its cytotoxicity, its potential inhalation toxicity is still largely unknown. As the pulmonary surfactant (PS) film is the first line of host defense, interaction with the PS film determines the fate of the inhaled nanomaterials and their potential toxicity. Using a coarse-grained molecular dynamics model, we reported, for the first time, a novel mechanism of toxicity caused by the inhaled GO nanosheets. Upon deposition, the GO nanosheets induce pores in the PS film and thus have adverse effects on the ultrastructure and biophysical properties of the PS film. Notably, the pores induced by GO nanosheets result in increasing the compressibility of the PS film, which is an important indication of surfactant inhibition. In vitro experiments have also been conducted to study the interactions between GO and animal-derived natural PS films, qualitatively confirming the simulation results. |
| DOI | 10.1039/c5nr05401j
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| URL | 查看原文
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| 收录类别 | SCI
; EI
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| 语种 | 英语
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| WOS记录号 | WOS:000364048900006
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| 关键词[WOS] | NANOPARTICLES
; TOXICITY
; TRANSLOCATION
; NANOPLATELETS
; NANOMATERIALS
; CYTOTOXICITY
; SIMULATIONS
; INHIBITION
; MONOLAYER
; SYSTEM
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| WOS研究方向 | Chemistry
; Science & Technology - Other Topics
; Materials Science
; Physics
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| WOS类目 | Chemistry, Multidisciplinary
; Nanoscience & Nanotechnology
; Materials Science, Multidisciplinary
; Physics, Applied
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| 项目资助者 | This work was financially supported by MOST 2011CB707604, NSFC 11272321 (G.H.), NSF Grant No. CBET-1236596 (Y.Y.Z.), and LNM Open Fund. The MD simulations were performed on TianHe-1(A) at the National Supercomputing Center in Tianjin. We thank Walter Klein at ONY Inc. for donation of Infasurf samples.
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| 课题组名称 | LNM微纳米流体力学
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| 论文分区 | 一类
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| 引用统计 |
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| 文献类型 | 期刊论文
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| 条目标识符 | http://dspace.imech.ac.cn/handle/311007/58389
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| 专题 | 非线性力学国家重点实验室
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| 通讯作者 | Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China. |
推荐引用方式
GB/T 7714 |
Hu QL,Jiao B,Shi XH,et al. Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film[J]. NANOSCALE,2015,7,43,:18025-18029.
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| APA |
Hu QL.,Jiao B.,施兴华.,Valle RP.,Zuo YY.,...&Hu, GQ .(2015).Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film.NANOSCALE,7(43),18025-18029.
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| MLA |
Hu QL,et al."Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film".NANOSCALE 7.43(2015):18025-18029.
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