Kinetics of Receptor-Ligand Interactions in Immune Responses

IMECH-IR > 力学所知识产出(1956-2008)

	Kinetics of Receptor-Ligand Interactions in Immune Responses
	Long M(龙勉); Lv SQ(吕守芹); Sun GY(孙淦云); Long, M (reprint author), Chinese Acad Sci, Inst Mech, Natl Micrograv Lab, Beijing 100080, Peoples R China.
发表期刊	CELLULAR & MOLECULAR IMMUNOLOGY
	2006
卷号	3 期号:2 页码:79-86
ISSN	1672-7681
摘要	Receptor-ligand interactions in blood flow are crucial to initiate the biological processes as inflammatory cascade, platelet thrombosis, as well as tumor metastasis. To mediate cell adhesions, the interacting receptors and ligands must be anchored onto two apposing surfaces of two cells or a cell and a substratum, i.e., the two-dimensional (2D) binding, which is different from the binding of a soluble ligand in fluid phase to a receptor, i.e., three-dimensional (3D) binding. While numerous works have been focused on 3D kinetics of receptor-ligand interactions in immune systems, 2D kinetics and its regulations have less been understood, since no theoretical framework and experimental assays have been established until 1993. Not only does the molecular structure dominate 2D binding kinetics, but the shear force in blood flow also regulates cell adhesions mediated by interacting receptors and ligands. Here we provided the overview of current progresses in 2D bindings and regulations. Relevant issues of theoretical frameworks, experimental measurements, kinetic rates and binding affinities, and force regulations, were discussed.
关键词	Kinetics Force Receptor-ligand Bond Cell Adhesion
收录类别	SCI
语种	英语
WOS记录号	WOS:000208926000001
WOS研究方向	Immunology
WOS类目	Immunology
项目资助者	NSFC [10332060, 30225027] ; CAS [KJCX2-SW-L06, 2005-1-16]
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/58455
专题	力学所知识产出(1956-2008)
通讯作者	Long, M (reprint author), Chinese Acad Sci, Inst Mech, Natl Micrograv Lab, Beijing 100080, Peoples R China.
推荐引用方式 GB/T 7714	Long M,Lv SQ,Sun GY,et al. Kinetics of Receptor-Ligand Interactions in Immune Responses[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2006,3,2,:79-86.
APA	龙勉,吕守芹,孙淦云,&Long, M .(2006).Kinetics of Receptor-Ligand Interactions in Immune Responses.CELLULAR & MOLECULAR IMMUNOLOGY,3(2),79-86.
MLA	龙勉,et al."Kinetics of Receptor-Ligand Interactions in Immune Responses".CELLULAR & MOLECULAR IMMUNOLOGY 3.2(2006):79-86.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
JourArSuppl2016-169.（524KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载