IMECH-IR  > 力学所知识产出(1956-2008)
Kinetics of Receptor-Ligand Interactions in Immune Responses
Long M(龙勉); Lv SQ(吕守芹); Sun GY(孙淦云); Long, M (reprint author), Chinese Acad Sci, Inst Mech, Natl Micrograv Lab, Beijing 100080, Peoples R China.
AbstractReceptor-ligand interactions in blood flow are crucial to initiate the biological processes as inflammatory cascade, platelet thrombosis, as well as tumor metastasis. To mediate cell adhesions, the interacting receptors and ligands must be anchored onto two apposing surfaces of two cells or a cell and a substratum, i.e., the two-dimensional (2D) binding, which is different from the binding of a soluble ligand in fluid phase to a receptor, i.e., three-dimensional (3D) binding. While numerous works have been focused on 3D kinetics of receptor-ligand interactions in immune systems, 2D kinetics and its regulations have less been understood, since no theoretical framework and experimental assays have been established until 1993. Not only does the molecular structure dominate 2D binding kinetics, but the shear force in blood flow also regulates cell adhesions mediated by interacting receptors and ligands. Here we provided the overview of current progresses in 2D bindings and regulations. Relevant issues of theoretical frameworks, experimental measurements, kinetic rates and binding affinities, and force regulations, were discussed.
KeywordKinetics Force Receptor-ligand Bond Cell Adhesion
Indexed BySCI
WOS IDWOS:000208926000001
WOS Research AreaImmunology
WOS SubjectImmunology
Funding OrganizationNSFC [10332060, 30225027] ; CAS [KJCX2-SW-L06, 2005-1-16]
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Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorLong, M (reprint author), Chinese Acad Sci, Inst Mech, Natl Micrograv Lab, Beijing 100080, Peoples R China.
Recommended Citation
GB/T 7714
Long M,Lv SQ,Sun GY,et al. Kinetics of Receptor-Ligand Interactions in Immune Responses[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2006,3(2):79-86.
APA 龙勉,吕守芹,孙淦云,&Long, M .(2006).Kinetics of Receptor-Ligand Interactions in Immune Responses.CELLULAR & MOLECULAR IMMUNOLOGY,3(2),79-86.
MLA 龙勉,et al."Kinetics of Receptor-Ligand Interactions in Immune Responses".CELLULAR & MOLECULAR IMMUNOLOGY 3.2(2006):79-86.
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