IMECH-IR  > 力学所知识产出(1956-2008)
The Mitogenic and Anti-Apoptotic Activity of Tumor Conditioned Medium on Endothelium
Li AL; Li HW; Zhang J; Jin G(靳刚); Xiu RJ; Xiu, RJ (reprint author), Chinese Acad Med Sci, Inst Microcirculat, Beijing 100005, Peoples R China.
Source PublicationCLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2003
Volume29Issue:3-4Pages:375-382
ISSN1386-0291
AbstractThis study was designed to observe the effect of tumor conditioned medium (TCM) on the proliferation and apoptosis of human umbilical vein endothelial cells (HUVECs). HUVECs were exposed to TCM from breast carcinoma cell line MDA-MB-231, then we measured their proliferation, apoptosis and cell cycle distribution by MTT and flow cytometery (FCM). Following the stimulation of TCM, HUVECs showed higher pro-mitogenic and anti-apoptotic ability than did the negative control group (ECGF-free medium with 20% FBS), but a similar ability to the positive control group (medium with ECGF and 20% FBS). From these results, we can conclude that breast carcinoma cell line MDA-MB-231 could secret soluble pro-angiogenic factors that induce HUVEC angiogenic switching, including cell cycle progression, proliferation and growth. The role and character of these factors remain to be further studied.
KeywordTumor Conditioned Medium Endothelium Proliferation Apoptosis Cell Cycle
Indexed BySCI
Language英语
WOS IDWOS:000188240800031
WOS KeywordGROWTH-FACTOR ; IN-VITRO ; ANGIOGENESIS ; CELLS ; IDENTIFICATION ; MODULATION ; EXPRESSION ; CULTURE
WOS Research AreaHematology ; Cardiovascular System & Cardiology
WOS SubjectHematology ; Peripheral Vascular Disease
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/58476
Collection力学所知识产出(1956-2008)
Corresponding AuthorXiu, RJ (reprint author), Chinese Acad Med Sci, Inst Microcirculat, Beijing 100005, Peoples R China.
Recommended Citation
GB/T 7714
Li AL,Li HW,Zhang J,et al. The Mitogenic and Anti-Apoptotic Activity of Tumor Conditioned Medium on Endothelium[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2003,29(3-4):375-382.
APA Li AL,Li HW,Zhang J,靳刚,Xiu RJ,&Xiu, RJ .(2003).The Mitogenic and Anti-Apoptotic Activity of Tumor Conditioned Medium on Endothelium.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,29(3-4),375-382.
MLA Li AL,et al."The Mitogenic and Anti-Apoptotic Activity of Tumor Conditioned Medium on Endothelium".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 29.3-4(2003):375-382.
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