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Optimization of Ligand Surface Concentration for Biosensor based on Imaging Ellipsometry
Niu Y(牛宇); Jin G(靳刚); Jin, G (reprint author), Chinese Acad Sci, Inst Mech, Beijing 100080, Peoples R China.
Source PublicationMICRO-AND NANOSYSTEMS IN MEDICINE, ACTIVE IMPLANTS, BIOSENSORS
2009
Conference NameWorld Congress on Medical Physics and Biomedical Engineering
Conference DateSEP 07-12, 2009
Conference PlaceMunich, GERMANY
Abstractthe biosensor based on imaging ellipsometry for bio-molecular interactions has been developed for more than ten years and used to several biological applications successfully, such as detection of five markers of Hepatitis B, tumor markers and virus infection. Ligand surface concentration which might be related with its spatial configuration and bioactivity is an important factor to affect the biosensor sensitivity and dynamic range. In this investigation, IgG and its corresponding antibody are selected as a couple of model molecules for the optimization of ligand surface concentration. The optimization result of ligand surface concentration is achieved by analyzing the surface concentration increase of antigen-antibody complex on sensing surface with various ligand surface concentrations.
WOS IDWOS:000291667000006
ISBN978-3-642-03886-0
Indexed ByCPCI-S
Language英语
Citation statistics
Document Type会议论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/58883
Collection国家微重力实验室
Corresponding AuthorJin, G (reprint author), Chinese Acad Sci, Inst Mech, Beijing 100080, Peoples R China.
Recommended Citation
GB/T 7714
Niu Y,Jin G,Jin, G . Optimization of Ligand Surface Concentration for Biosensor based on Imaging Ellipsometry[C]. NEW YORK, 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES:SPRINGER,2009.
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