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Binding affinity analysis of the interaction between Homer EVH domain and ryanodine receptor with biosensors based on imaging ellipsometry
Kang TF(康腾飞); Zhang KM; Yin CC; Niu Y(牛宇); Jin G(靳刚); Niu, Y; Jin, G (reprint author), Chinese Acad Sci, Inst Mech, NML, 15 Bei Si Huan West Rd, Beijing 100190, Peoples R China.; Jin, G (reprint author), Chinese Acad Sci, Beijing Key Lab Engn Construct & Mechanobiol, Inst Mech, 15 Bei Si Huan West Rd, Beijing 100190, Peoples R China.
Source PublicationANALYTICAL METHODS
2016
Volume8Issue:14Pages:2936-2940
ISSN1759-9660
AbstractThe interaction between the Homer EVH domain and RyR plays an important role in calcium signaling channels in the heart and the skeletal muscles. A biosensor based on imaging ellipsometry was used to analyze the binding affinity between the Homer EVH domain and RyR. The results confirm that the Homer EVH domain can recognize RyR specifically with high binding affinity of approximately 10(-8) M. This information will contribute to understanding of the role of the interaction between the Homer EVH domain and RyR in intracellular calcium channels.
DOI10.1039/c6ay00089d
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000373440600010
WOS Research AreaChemistry ; Food Science & Technology ; Spectroscopy
WOS SubjectChemistry, Analytical ; Food Science & Technology ; Spectroscopy
Funding OrganizationThe authors acknowledge the financial support of the International Science & Technology Cooperation Program of China (2015DFG32390), the 7th Sino-Portugal Scientific and Technological Cooperation of 2013-2015, the National Basic Research Program of China (2015CB352100), and the National Natural Science Foundation of China (21305147) and (81472941).
DepartmentNML纳米生物光学
Classification二类
RankingTrue
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/59521
Collection国家微重力实验室
Corresponding AuthorNiu, Y; Jin, G (reprint author), Chinese Acad Sci, Inst Mech, NML, 15 Bei Si Huan West Rd, Beijing 100190, Peoples R China.; Jin, G (reprint author), Chinese Acad Sci, Beijing Key Lab Engn Construct & Mechanobiol, Inst Mech, 15 Bei Si Huan West Rd, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Kang TF,Zhang KM,Yin CC,et al. Binding affinity analysis of the interaction between Homer EVH domain and ryanodine receptor with biosensors based on imaging ellipsometry[J]. ANALYTICAL METHODS,2016,8(14):2936-2940.
APA 康腾飞.,Zhang KM.,Yin CC.,牛宇.,靳刚.,...&Jin, G .(2016).Binding affinity analysis of the interaction between Homer EVH domain and ryanodine receptor with biosensors based on imaging ellipsometry.ANALYTICAL METHODS,8(14),2936-2940.
MLA 康腾飞,et al."Binding affinity analysis of the interaction between Homer EVH domain and ryanodine receptor with biosensors based on imaging ellipsometry".ANALYTICAL METHODS 8.14(2016):2936-2940.
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