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The Mechanical Analysis of the Biofilm Streamer Nucleation and Geometry Characterization in Microfluidic Channels
Wang XL; Hao MD; Du X; Wang GQ; Matsushita J; Wang, XL (reprint author), Univ Sci & Technol Beijing, Sch Mech Engn, Beijing 100083, Peoples R China.; Wang, XL (reprint author), Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.; Wang, XL (reprint author), Chinese Acad Sci, Inst Mech, Lab Nonlinear Mech, Beijing 100190, Peoples R China.
Source PublicationCOMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
2016
Pages7819403
ISSN1748-670X
AbstractBacteria can form biofilm streamers in microfluidic channels with various geometries. Experiments show that the streamer geometry, such as its shape or thickness, depends on the fluid velocity and the geometry and curvature of the microfluidic channel. In the paper, a mechanical analysis of the flow field is made in different channels, which shows that the secondary flow in the channel is the reason for streamer nucleation and that the shear stress distribution decides the streamer geometry including shape and thickness. Through a finite elements simulation, we obtain the secondary flow forming positions in both static and rotating channels: positions that are the location of nucleation of the streamer. Thick or wide biofilm streamers occur at the points of minimum shear stress in static channels. Furthermore, in rotating channels, spiral-like streamers form, due to the helical shape of the minimum shear stress distribution. The findings may allow the prevention of biofilm formation and also the removal of bacteria adhered onto certain surfaces in channels with small cross sections. The analysis also indicates how one can obtain desirable biofilm streamers by control of the channel geometry and the loading conditions.
KeywordGradient Structure Strain Hardening Ductility Transformation-induced Plasticity Strain Partitioning
DOI10.1155/2016/7819403
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000377886400001
WOS KeywordGradient structure ; Strain hardening ; Ductility ; Transformation-induced plasticity ; Strain partitioning
WOS Research AreaMathematical & Computational Biology
WOS SubjectMathematical & Computational Biology
Funding OrganizationThe work was supported by Harvard University, the National Natural Science Foundation of China (11272002), Beijing Education Young Elite Teacher Project (YETP0363), and Opening Fund of State Key Laboratory of Nonlinear Mechanics.
ClassificationQ4
RankingFalse
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/59527
Collection非线性力学国家重点实验室
Corresponding AuthorWang, XL (reprint author), Univ Sci & Technol Beijing, Sch Mech Engn, Beijing 100083, Peoples R China.; Wang, XL (reprint author), Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.; Wang, XL (reprint author), Chinese Acad Sci, Inst Mech, Lab Nonlinear Mech, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Wang XL,Hao MD,Du X,et al. The Mechanical Analysis of the Biofilm Streamer Nucleation and Geometry Characterization in Microfluidic Channels[J]. COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE,2016:7819403.
APA Wang XL.,Hao MD.,Du X.,Wang GQ.,Matsushita J.,...&Wang, XL .(2016).The Mechanical Analysis of the Biofilm Streamer Nucleation and Geometry Characterization in Microfluidic Channels.COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE,7819403.
MLA Wang XL,et al."The Mechanical Analysis of the Biofilm Streamer Nucleation and Geometry Characterization in Microfluidic Channels".COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE (2016):7819403.
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