IMECH-IR  > 非线性力学国家重点实验室
Nonspecific Organelle-Targeting Strategy with Core-Shell Nanoparticles of Varied Lipid Components/Ratios
Zhang L; Sun JS; Wang YL; Wang JC; Shi XH; Hu GQ(胡国庆); Sun, JS (reprint author), Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
Source PublicationANALYTICAL CHEMISTRY
2016
Volume88Issue:14Pages:7344-7351
ISSN0003-2700
Abstract

We report a nonspecific organelle-targeting strategy through one-step microfluidic fabrication and screening of a library of surface charge- and lipid components/ratios-varied lipid shell polymer core nanoparticles. Different from the common strategy relying on the use of organelle-targeted moieties conjugated onto the surface of nanoparticles, here, we program the distribution of hybrid nanoparticles in lysosomes or mitochondria by tuning the lipid components/ratios in shell. Hybrid nanoparticles with 60% 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) and 20% 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) can intracellularly target mitochondria in both in vitro and in vivo models. While replacing DOPE with the same amount of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), the nanoparticles do not show mitochondrial targeting, indicating an incremental effect of cationic and fusogenic lipids on lysosomal escape which is further studied by molecular dynamics simulations. This work unveils the lipid-regulated subcellular distribution of hybrid nanoparticles in which target moieties and complex synthetic steps are avoided.

DOI10.1021/acs.analchem.6b01749
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000380296800054
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
Funding OrganizationWe acknowledge financial support from MOST (2013AA032204), NSFC (21475028, 11422215, 11272327, and 11023001), and Youth Innovation Promotion Association CAS.
DepartmentLNM微纳米流体力学
Classification一类
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/59761
Collection非线性力学国家重点实验室
Corresponding AuthorSun, JS (reprint author), Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Zhang L,Sun JS,Wang YL,et al. Nonspecific Organelle-Targeting Strategy with Core-Shell Nanoparticles of Varied Lipid Components/Ratios[J]. ANALYTICAL CHEMISTRY,2016,88(14):7344-7351.
APA Zhang L.,Sun JS.,Wang YL.,Wang JC.,Shi XH.,...&Sun, JS .(2016).Nonspecific Organelle-Targeting Strategy with Core-Shell Nanoparticles of Varied Lipid Components/Ratios.ANALYTICAL CHEMISTRY,88(14),7344-7351.
MLA Zhang L,et al."Nonspecific Organelle-Targeting Strategy with Core-Shell Nanoparticles of Varied Lipid Components/Ratios".ANALYTICAL CHEMISTRY 88.14(2016):7344-7351.
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