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Title:
Nonspecific Organelle-Targeting Strategy with Core-Shell Nanoparticles of Varied Lipid Components/Ratios
Author: Zhang L; Sun JS; Wang YL; Wang JC; Shi, XingHua(施兴华); Hu GQ(胡国庆)
Source: ANALYTICAL CHEMISTRY
Issued Date: 2017
Volume: 88, Issue:14, Pages:7344-7351
Abstract: We report a nonspecific organelle-targeting strategy through one-step microfluidic fabrication and screening of a library of surface charge- and lipid components/ratios-varied lipid shell polymer core nanoparticles. Different from the common strategy relying on the use of organelle-targeted moieties conjugated onto the surface of nanoparticles, here, we program the distribution of hybrid nanoparticles in lysosomes or mitochondria by tuning the lipid components/ratios in shell. Hybrid nanoparticles with 60% 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) and 20% 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) can intracellularly target mitochondria in both in vitro and in vivo models. While replacing DOPE with the same amount of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), the nanoparticles do not show mitochondrial targeting, indicating an incremental effect of cationic and fusogenic lipids on lysosomal escape which is further studied by molecular dynamics simulations. This work unveils the lipid-regulated subcellular distribution of hybrid nanoparticles in which target moieties and complex synthetic steps are avoided.
Language: 英语
Indexed Type: SCI ; EI
Corresponding Author: Sun, JS (reprint author), Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
Correspondent Email: sunjs@nanoctr.cn
DOI: 10.1021/acs.analchem.6b01749
Related URLs: 查看原文
DOC Type: 期刊论文
WOS Subject: Chemistry, Analytical
WOS Subject Extended: Chemistry
WOS ID: WOS:000380296800054
ISSN: 0003-2700
Funder: We acknowledge financial support from MOST (2013AA032204), NSFC (21475028, 11422215, 11272327, and 11023001), and Youth Innovation Promotion Association CAS.
Rank: [Zhang, Lu] Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China; [Sun, Jiashu; Shi, Xinghua] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; [Wang, Yilian; Wang, Jiancheng] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; [Hu, Guoqing] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
Department: LNM微纳米流体力学
Classification: 一类
Ranking: false
Citation statistics:
Content Type: 期刊论文
URI: http://dspace.imech.ac.cn/handle/311007/59761
Appears in Collections:非线性力学国家重点实验室_期刊论文

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Recommended Citation:
Zhang L,Sun JS,Wang YL,et al. Nonspecific Organelle-Targeting Strategy with Core-Shell Nanoparticles of Varied Lipid Components/Ratios[J]. ANALYTICAL CHEMISTRY,2017-01-01,88(14):7344-7351.
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